N-[(1S)-2-(methoxymethoxy)-1-phenylethyl]acetamide

Base Information

Chemical Name:N-[(1S)-2-(methoxymethoxy)-1-phenylethyl]acetamide
CAS No.:217650-36-7
Molecular Formula:C12H17NO3
Molecular Weight:223.272
Hs Code.:
DSSTox Substance ID:DTXSID40441079
Wikidata:Q82257655
Mol file:217650-36-7.mol

Synonyms:N-[(1S)-2-(methoxymethoxy)-1-phenylethyl]acetamide;217650-36-7;SCHEMBL7733440;DTXSID40441079

Suppliers and Price of N-[(1S)-2-(methoxymethoxy)-1-phenylethyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of N-[(1S)-2-(methoxymethoxy)-1-phenylethyl]acetamide

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:223.12084340
Heavy Atom Count:16
Complexity:202

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC(COCOC)C1=CC=CC=C1
Isomeric SMILES:CC(=O)N[C@H](COCOC)C1=CC=CC=C1

Technology Process of N-[(1S)-2-(methoxymethoxy)-1-phenylethyl]acetamide

There total 4 articles about N-[(1S)-2-(methoxymethoxy)-1-phenylethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 217650-28-7
N-(2-methoxymethoxy-1-phenyl-vinyl)-acetamide

: 217650-36-7
N-(2-methoxymethoxy-1-phenyl-ethyl)-acetamide

Guidance literature:: With hydrogen; [R,R-RhMe-Duphos]; In toluene; at 20 ℃; under 7600 Torr;
DOI:10.1021/jo981590a

Reference yield:

: 582-24-1
1-phenyl-2-hydroxyethanone

: 217650-36-7
N-(2-methoxymethoxy-1-phenyl-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: LiH / dimethylformamide

2: H₂NOH*HCl; NaOAc / ethanol; H₂O

3: Fe / dimethylformamide

4: 100 percent / H₂ / {1,2-bis[(R,R)-2,5-dimethylphospholane]benzene}rhodium(I) / toluene / 20 °C / 7600 Torr

With hydroxylamine hydrochloride; hydrogen; sodium acetate; iron; lithium hydride; [R,R-RhMe-Duphos]; In ethanol; water; N,N-dimethyl-formamide; toluene; 1: Etherification / 2: Condensation / 3: Reduction / 4: Catalytic hydrogenation;
DOI:10.1021/jo981590a

Reference yield:

: 103548-06-7
2-methoxymethoxy-1-phenyl-ethanone

: 217650-36-7
N-(2-methoxymethoxy-1-phenyl-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂NOH*HCl; NaOAc / ethanol; H₂O

2: Fe / dimethylformamide

3: 100 percent / H₂ / {1,2-bis[(R,R)-2,5-dimethylphospholane]benzene}rhodium(I) / toluene / 20 °C / 7600 Torr

With hydroxylamine hydrochloride; hydrogen; sodium acetate; iron; [R,R-RhMe-Duphos]; In ethanol; water; N,N-dimethyl-formamide; toluene; 1: Condensation / 2: Reduction / 3: Catalytic hydrogenation;
DOI:10.1021/jo981590a