103548-06-7

Basic information

• Product Name: Ethanone, 2-(methoxymethoxy)-1-phenyl-
• CAS NO: 103548-06-7
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol File: 103548-06-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(methoxymethoxy)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(methoxymethoxy)-1-phenyl-(103548-06-7)
• EPA Substance Registry System: Ethanone, 2-(methoxymethoxy)-1-phenyl-(103548-06-7)

Safety Data

• Hazardous Substances Data: 103548-06-7(Hazardous Substances Data)

Upstream product

• 107-30-2 chloromethyl methyl ether 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 108-22-5 Isopropenyl acetate 
• 115384-56-0 2-(methoxymethoxy)-1-phenylethanol 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 181048-90-8 2-(2'-methoxymethyloxyphenyl)quinoline-4-carboxylic acid 
• 1311260-37-3 (R)-2-phenyl-2-vinylpent-4-en-1-ol 
• 1311260-35-1 (R)-(3-((methoxymethoxy)methyl)hexa-1,5-dien-3-yl)benzene 
• 1311260-15-7 tert-butyl (1-(methoxymethoxy)-2-phenylbut-3-en-2-yl) carbonate 
• 1393380-69-2 C₁₂H₁₆O₄ 
• 115384-56-0 (S)-2-(methoxymethoxy)-1-phenylethanol 
• 103548-10-3 (R)-2-(methoxymethoxy)-1-phenylethanol 
• 115384-56-0 2-(methoxymethoxy)-1-phenylethanol 
• 1441180-92-2 4-ethoxy-1-(methoxymethoxy)-2-phenylbut-3-yn-2-ol 
• 1441181-47-0 3-iodo-4-phenylfuran-2(5H)-one 
• 5635-16-5 3,4-diphenyl-2(5H)-furanone 
• 885065-17-8 5-(2,5-difluorophenyl)-2-((methoxymethoxy)methyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazole 
• 217650-36-7 N-(2-methoxymethoxy-1-phenyl-ethyl)-acetamide 
• 217650-28-7 N-(2-methoxymethoxy-1-phenyl-vinyl)-acetamide 

Relevant articles and documents

Identification of a novel neuropeptide s receptor antagonist scaffold based on the sha-68 core

Activation of the neuropeptide S receptor (NPSR) system has been shown to produce an-xiolytic-like actions, arousal, and enhance memory consolidation, whereas blockade of the NPSR has been shown to reduce relapse to substances of abuse and duration of anesthetics. We report here the discovery of a novel core scaffold (+) N-benzyl-3-(2-methylpropyl)-1-oxo-3-phenyl-1H,3H,4H,5H,6H,7H-furo[3,4-c]pyridine-5-carboxamide with potent NPSR antagonist activity in vitro. Pharmacokinetic parameters demonstrate that 14b reaches pharmacologically relevant levels in plasma and the brain following intraperitoneal (i.p.) administration, but is cleared rapidly from plasma. Compound 14b was able to block NPS (0.3 nmol)-stimulated locomotor activity in C57/Bl6 mice at 3 mg/kg (i.p.), indicating potent in vivo activity for the structural class. This suggests that 14b can serve as a useful tool for continued mapping of the pharmacological functions of the NPS receptor system.

Enantioselective construction of all-carbon quaternary centers by branch-selective Pd-catalyzed allyl-allyl cross-coupling

The Pd-catalyzed cross-coupling of racemic tertiary allylic carbonates and allylboronates is described. This reaction generates all-carbon quaternary centers in a highly regioselective and enantioselective fashion. The outcome of these reactions is consistent with a process that proceeds by way of 3,3′-reductive elimination of bis(η1-allyl)palladium intermediates. Strategies for distinguishing the product alkenes and application to the synthesis of (+)-α-cuparenone are also described.

Mitotic kinesin inhibitors and methods of use thereof

This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.