5-(4-Benzyloxy-3,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine

Base Information

• Chemical Name: 5-(4-Benzyloxy-3,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine
• CAS No.: 21822-34-4
• Molecular Formula: C20H22N4O3
• Molecular Weight: 366.42
• DSSTox Substance ID: DTXSID70878490
• Nikkaji Number: J1.605.948J
• Wikidata: Q82860530
• ChEMBL ID: CHEMBL279509
• Mol file: 21822-34-4.mol

Synonyms:CHEMBL279509;21822-34-4;SCHEMBL10912233;DTXSID70878490;BDBM50110756;24NH2-PYRIMIDINE,5(35MEO-4PHMEO)BENZYL;5-(4-Benzyloxy-3,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine;5-[3,5-Dimethoxy-4-(benzyloxy)benzyl]-2,4-pyrimidinediamine

Chemical Property of 5-(4-Benzyloxy-3,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 7
• Exact Mass: 366.16919058
• Heavy Atom Count: 27
• Complexity: 421

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OCC2=CC=CC=C2)OC)CC3=CN=C(N=C3N)N

Technology Process of 5-(4-Benzyloxy-3,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine

There total 3 articles about 5-(4-Benzyloxy-3,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzyl bromide (100-39-0) + 2,4-diamino-5-(3,5-dimethoxy-4-hydroxybenzyl)pyrimidine (21253-58-7) → 5-(4-(benzyloxy)-3,5-dimethoxybenzyl)pyrimidine-2,4-diamine (21822-34-4)

Guidance literature:

With potassium carbonate; In acetonitrile; at 40 - 45 ℃;

DOI:10.1016/j.bmcl.2016.10.051

Reference yield:

5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine (738-70-5) → 5-(4-(benzyloxy)-3,5-dimethoxybenzyl)pyrimidine-2,4-diamine (21822-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide / 20 - 100 °C

2: potassium carbonate / acetonitrile / 40 - 45 °C

With hydrogen bromide; potassium carbonate; In acetonitrile;

DOI:10.1016/j.bmcl.2016.10.051

Reference yield:

→ 5-(4-(benzyloxy)-3,5-dimethoxybenzyl)pyrimidine-2,4-diamine (21822-34-4)

Guidance literature:

entspr. 4-Hydroxybenzyl-Verb., Benzylbromid;

upstream raw materials:

benzyl bromide

2,4-diamino-5-(3,5-dimethoxy-4-hydroxybenzyl)pyrimidine

5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine