(1R,2R)-1,2-Bis(4-fluorophenyl)-1,2-ethanediol

Base Information

Chemical Name:(1R,2R)-1,2-Bis(4-fluorophenyl)-1,2-ethanediol
CAS No.:220091-30-5
Molecular Formula:C14H12F2O2
Molecular Weight:250.245
Hs Code.:
DSSTox Substance ID:DTXSID50427586
Nikkaji Number:J1.009.327I
Wikidata:Q82240249
Mol file:220091-30-5.mol

Synonyms:AC1OEJ8E;220091-30-5;(1R,2R)-1,2-Bis(4-fluorophenyl)-1,2-ethanediol;DTXSID50427586

Suppliers and Price of (1R,2R)-1,2-Bis(4-fluorophenyl)-1,2-ethanediol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (1R,2R)-1,2-Bis(4-fluorophenyl)-1,2-ethanediol

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:250.08053595
Heavy Atom Count:18
Complexity:220

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C(C(C2=CC=C(C=C2)F)O)O)F
Isomeric SMILES:C1=CC(=CC=C1[C@H]([C@@H](C2=CC=C(C=C2)F)O)O)F

Technology Process of (1R,2R)-1,2-Bis(4-fluorophenyl)-1,2-ethanediol

There total 6 articles about (1R,2R)-1,2-Bis(4-fluorophenyl)-1,2-ethanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 588-56-7,40286-61-1,146565-92-6,146565-94-8,27764-15-4
(E)-1,2-di(4-fluorophenyl)ethene

: 220091-30-5
(R,R)-(+)-1,2-di(p-fluorophenyl)ethane-1,2-diol

Guidance literature:: With methanesulfonamide; 1,4-bis(9-O-dihydroquinidine)phthalazine; In water; tert-butyl alcohol; for 20h; Ambient temperature;
DOI:10.1016/S0040-4020(98)00987-9

Reference yield:

: 579-39-5
1,2-bis(4-fluorophenyl)ethane-1,2-dione

: 53458-16-5
1,2-bis(4-fluorophenyl)-2-hydroxyethan-1-one

: 119441-83-7
meso-1,2-bis(4-fluorophenyl)ethane-1,2-diol

: 220091-30-5
(R,R)-(+)-1,2-di(p-fluorophenyl)ethane-1,2-diol

Guidance literature:: With formic acid; triethylamine; RuCl[(1S,2S)-TsDPEN](η⁶-p-cymene); at 40 ℃; for 24h;
DOI:10.1021/ol990226a

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 119441-83-7
meso-1,2-bis(4-fluorophenyl)ethane-1,2-diol

: 220091-30-5
(R,R)-(+)-1,2-di(p-fluorophenyl)ethane-1,2-diol

: 1003010-61-4
(1S,2S)-1,2-bis-(4-fluoro-phenyl)-ethane-1,2-diol

Guidance literature:: 4-fluorobenzaldehyde; With chloro-trimethyl-silane; Ti-(R,R-SALEN); zinc; In acetonitrile; at -10 ℃; for 5h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.166667h; Title compound not separated from byproducts;
DOI:10.1021/jo0342875