Z-Tyr(3-tBu)-OMe

Base Information

Chemical Name:Z-Tyr(3-tBu)-OMe
CAS No.:220808-33-3
Molecular Formula:C22H27NO5
Molecular Weight:385.46
Hs Code.:
DSSTox Substance ID:DTXSID001147918
Mol file:220808-33-3.mol

Synonyms:Z-Tyr(3-tBu)-OMe;Z-Tyr(3-t-Bu)-OMe;IQQXJQWQWXUKQX-SFHVURJKSA-N;DTXSID001147918;220808-33-3;3-(1,1-Dimethylethyl)-N-[(phenylmethoxy)carbonyl]-L-tyrosine methyl ester

Suppliers and Price of Z-Tyr(3-tBu)-OMe

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of Z-Tyr(3-tBu)-OMe

Chemical Property:

XLogP3:4.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:385.18892296
Heavy Atom Count:28
Complexity:510

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C1=C(C=CC(=C1)CC(C(=O)OC)NC(=O)OCC2=CC=CC=C2)O
Isomeric SMILES:CC(C)(C)C1=C(C=CC(=C1)C[C@@H](C(=O)OC)NC(=O)OCC2=CC=CC=C2)O

Technology Process of Z-Tyr(3-tBu)-OMe

There total 3 articles about Z-Tyr(3-tBu)-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 287207-43-6
methyl 3-tert-butyltyrosinate

: 501-53-1,94274-21-2
benzyl chloroformate

: 220808-33-3
N-Cbz-L-(2-t-Bu)-Tyr-OMe

Guidance literature:: With sodium carbonate; In 1,4-dioxane; water;
DOI:10.1016/j.bmcl.2009.05.059

Reference yield:

: 60-18-4,18875-48-4,25619-78-7,30704-25-7
L-tyrosine

: 220808-33-3
N-Cbz-L-(2-t-Bu)-Tyr-OMe

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 0 - 20 °C / Inert atmosphere

2.1: methanesulfonic acid / 12 h / 50 °C

3.1: sodium carbonate / water; tetrahydrofuran / 25 °C

3.2: 16 h / 0 - 20 °C

With thionyl chloride; methanesulfonic acid; sodium carbonate; In tetrahydrofuran; water;
DOI:10.1002/anie.201913305

Reference yield:

: 3417-91-2
L-tyrosine methyl ester HCl

: 220808-33-3
N-Cbz-L-(2-t-Bu)-Tyr-OMe

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanesulfonic acid / 12 h / 50 °C

2.1: sodium carbonate / water; tetrahydrofuran / 25 °C

2.2: 16 h / 0 - 20 °C

With methanesulfonic acid; sodium carbonate; In tetrahydrofuran; water;
DOI:10.1002/anie.201913305