Propanedioic acid, [4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-oxo-3-(pentylamino) propyl]phenoxy]-, bis(phenylmethyl) ester

Base Information

• Chemical Name: Propanedioic acid, [4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-oxo-3-(pentylamino) propyl]phenoxy]-, bis(phenylmethyl) ester
• CAS No.: 221077-07-2
• Molecular Formula: C36H44N2O8
• Molecular Weight: 632.754
• Mol file: 221077-07-2.mol

Synonyms:

Chemical Property of Propanedioic acid, [4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-oxo-3-(pentylamino) propyl]phenoxy]-, bis(phenylmethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanedioic acid, [4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-oxo-3-(pentylamino) propyl]phenoxy]-, bis(phenylmethyl) ester

There total 1 articles about Propanedioic acid, [4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-oxo-3-(pentylamino) propyl]phenoxy]-, bis(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

dibenzyl 2-bromomalonate (65100-24-5) + tert-butyl (1S)-1-(4-hydroxybenzyl)-2-oxo-2-(pentylamino)ethylcarbamate (221076-98-8) → dibenzyl 2-{4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy}malonate (221077-07-2)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃;

DOI:10.1021/jm010393s

Reference yield: 98.0%

dibenzyl 2-{4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy}malonate (221077-07-2) → dibenzyl 2-{4-[(2S)-2-amino-3-oxo-3-(pentylamino)propyl]phenoxy}malonate hydrochloride

Guidance literature:

With hydrogenchloride; acetic acid; at 20 ℃; for 2h;

DOI:10.1021/jm010393s

Reference yield:

dibenzyl 2-{4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy}malonate (221077-07-2) → (S)-[4-[2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-oxo-3-(pentylamino)propyl]phenoxy]propanedioic acid (221075-31-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 3h; under 750.075 Torr;

upstream raw materials:

dibenzyl 2-bromomalonate

tert-butyl (1S)-1-(4-hydroxybenzyl)-2-oxo-2-(pentylamino)ethylcarbamate