Naphazoline IMpurity D

Base Information

• Chemical Name: Naphazoline IMpurity D
• CAS No.: 22126-67-6
• Molecular Formula: C14H14N2
• Molecular Weight: 210.27400
• Mol file: 22126-67-6.mol

Synonyms:naphazoline;Naphazoline Impurity D;2-(2-naphthylmethyl)imidazoline;Naphazolin;2-naphthalen-2-ylmethyl-4,5-dihydro-1H-imidazole;

Chemical Property of Naphazoline IMpurity D

Chemical Property:

• Melting Point: 108-111°C
• PSA: 24.39000
• LogP: 2.14840
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

2-(Naphthalen-2-ylmethyl)-4,5-dihydro-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(Naphthalen-2-ylmethyl)-4,5-dihydro-1H-imidazole is an impurity compound of Naphazoline (N343950, N756953). An intermediate used in the preparation of other novel 2-substituted 4,5-dihydro-1H-imidazole derivatives with antidepressant properties.

Technology Process of Naphazoline IMpurity D

There total 2 articles about Naphazoline IMpurity D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-naphthaleneacetonitrile (7498-57-9) + ethylenediamine (107-15-3,85404-18-8) → naphazoline (22126-67-6)

Guidance literature:

With trimethylaluminum; Yield given. Multistep reaction; 1.) toluene, 1 h, 2.) reflux, 18 h;

DOI:10.1021/jm00391a034

Reference yield:

→ naphazoline (22126-67-6)

Guidance literature:

upstream raw materials:

2-naphthaleneacetonitrile

ethylenediamine

Refernces

• 1、 -. "Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives". Page/Page column 43; 48. . Retrieved 2010/11/28.