Spiro[3.5]non-7-en-6-one

Base Information

• Chemical Name: Spiro[3.5]non-7-en-6-one
• CAS No.: 221342-49-0
• Molecular Formula: C9H12O
• Molecular Weight: 136.194
• DSSTox Substance ID: DTXSID10450734
• Wikidata: Q82270540
• Mol file: 221342-49-0.mol

Synonyms:Spiro[3.5]non-7-en-6-one;221342-49-0;spiro[3.5]non-6-en-8-one;starbld0042984;SCHEMBL5741689;DTXSID10450734;FT-0768009;EN300-7465102

Chemical Property of Spiro[3.5]non-7-en-6-one

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 136.088815002
• Heavy Atom Count: 10
• Complexity: 187

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2(C1)CC=CC(=O)C2

Technology Process of Spiro[3.5]non-7-en-6-one

There total 1 articles about Spiro[3.5]non-7-en-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

spiro[3.5]nonane-6,8-dione (221342-48-9) → spiro[3.5]non-7-en-6-one (221342-49-0)

Guidance literature:

spiro[3.5]nonane-6,8-dione; With 2-methyl-propan-1-ol; toluene-4-sulfonic acid; In toluene; Heating;

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 40 - 50 ℃;

DOI:10.1002/(SICI)1521-3773(19991115)38:22<3373::AID-ANIE3373>3.0.CO;2-F

Reference yield: 65.0%

2-(trimethylsilyloxy)-3-methyl-1-butene (17510-45-1) + spiro[3.5]non-7-en-6-one (221342-49-0) + 1-(4-fluorophenyl)-3-(4-trifluoromethylphenyl)-propen-3-one (256424-38-1) → C30H32F4O3 (221342-43-4)

Guidance literature:

2-(trimethylsilyloxy)-3-methyl-1-butene; spiro[3.5]non-7-en-6-one; With titanium(IV) isopropylate; titanium tetrachloride; In dichloromethane;

1-(4-fluorophenyl)-3-(4-trifluoromethylphenyl)-propen-3-one; In dichloromethane;

DOI:10.2533/000942904777678082

Reference yield: 42.0%

2-(trimethylsilyloxy)-3-methyl-1-butene (17510-45-1) + spiro[3.5]non-7-en-6-one (221342-49-0) + 1-(4-fluorophenyl)-3-(4-trifluoromethylphenyl)-propen-3-one (256424-38-1) → C30H32F4O3

Guidance literature:

With titanium(IV) isopropylate; titanium tetrachloride; In dichloromethane; at -7 - 20 ℃; for 2.16667h;

DOI:10.1002/(SICI)1521-3773(19991115)38:22<3373::AID-ANIE3373>3.0.CO;2-F

upstream raw materials:

spiro[3.5]nonane-6,8-dione

Downstream raw materials:

C₃₀H₃₂F₄O₃

C₃₀H₂₆F₄O₂

C₃₀H₂₈F₄O₂

C₃₆H₄₃F₅OSi