2-(4-Chlorophenyl)-4-phenyl-1,3-thiazole

Base Information

• Chemical Name: 2-(4-Chlorophenyl)-4-phenyl-1,3-thiazole
• CAS No.: 2227-72-7
• Molecular Formula: C15H10ClNS
• Molecular Weight: 271.77
• DSSTox Substance ID: DTXSID60356717
• Nikkaji Number: J1.050.647F
• Wikidata: Q82136252
• Mol file: 2227-72-7.mol

Synonyms:2-(4-chlorophenyl)-4-phenyl-1,3-thiazole;2227-72-7;Thiazole, 2-(4-chlorophenyl)-4-phenyl-;2-(4-Chlorophenyl)-4-phenylthiazole;SCHEMBL11455457;DTXSID60356717;STK816706;AKOS002233095;FT-0733830;AF-399/41895789

Chemical Property of 2-(4-Chlorophenyl)-4-phenyl-1,3-thiazole

Chemical Property:

• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 271.0222482
• Heavy Atom Count: 18
• Complexity: 259

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CSC(=N2)C3=CC=C(C=C3)Cl

Technology Process of 2-(4-Chlorophenyl)-4-phenyl-1,3-thiazole

There total 17 articles about 2-(4-Chlorophenyl)-4-phenyl-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-phenyl-2-(p-tolylsulfonyloxy)ethanone (7257-94-5) + 4-chlorothiobenzamide (2521-24-6) → 2-(4′-chlorophenyl)-4-phenylthiazole (2227-72-7)

Guidance literature:

With montmorillonite K-10; at 130 ℃; for 0.05h;

DOI:10.1039/a807563h

Reference yield: 79.0%

4-(4-chloro-thiobenzoyl)-morpholine (21011-44-9) + 1-(1-azido-2-iodoethyl)benzene (4098-17-3) → 2-(4′-chlorophenyl)-4-phenylthiazole (2227-72-7)

Guidance literature:

With potassium tert-butylate; at 80 ℃; for 7h;

DOI:10.1021/acscombsci.9b00045

Reference yield: 79.0%

→ 2-(4′-chlorophenyl)-4-phenylthiazole (2227-72-7)

Guidance literature:

With triethylamine; In ethanol; at 80 ℃; for 0.333333h; under 10343.2 Torr; Microwave irradiation;

upstream raw materials:

4-Chloro-dithiobenzoic acid 2-[(E)-hydroxyimino]-2-phenyl-ethyl ester

4-Chloro-dithiobenzoic acid 2-oxo-2-phenyl-ethyl ester

1-phenyl-2-(p-tolylsulfonyloxy)ethanone

4-chlorothiobenzamide

Refernces

• 1、 -. "Preparation method of 2, 4-disubstituted thiazole compound". Paragraph 0034; 0041-0044; 0061-0064. . Retrieved 2020/11/23.
• 2、 Wang, Zi-Juan,Chen, Wen-Teng,He, Chang,Luo, Hao-Fan,Zhang, Guo-Lin,Yu, Yong-Ping. "Cascade reactions to 2,4-disubstituted thiazoles via ligand-free palladium(II)-catalyzed C(sp)–C(sp2) coupling". . . Retrieved 2020/01/28.