7257-94-5Relevant academic research and scientific papers
Novel preparation and reactivity of poly[4-hydroxy(tosyloxy)iodo]styrenes
Abe,Sakuratani,Togo
, p. 22 - 24 (2001)
Poly[4-hydroxy(tosyloxy)iodo]styrene (high M.W.) and poly{α-methyl[4-hydroxy(tosyloxy)iodo]styrene} (low M.W.) were prepared from polystyrene (average M.W. = 45,000) and poly(α-methylstyrene) (average M.W. = 6,200), respectively, and their reactivities fo
Synthesis method of alpha-carbonyl sulfonate and catalyst used in synthesis method
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Paragraph 0076-0082; 0086, (2021/04/17)
The invention provides a nitrogen and carbon co-doped Nb2O5 catalyst for synthesizing alpha carbonyl sulfonate, a preparation method of the nitrogen and carbon co-doped Nb2O5 catalyst, and a synthesizing method of the alpha carbonyl sulfonate by using the catalyst under the driving of visible light. Based on the total weight of the catalyst, the content of nitrogen is 0.01 wt%-1wt%; the content of the carbon is 0.01 wt% to 1.5 wt%. The catalyst provided by the invention is used for preparing alpha-carbonyl sulfonate through olefin aerobic oxidation, the reaction condition is mild, oxygen is used as an oxidant, and other oxidants are not needed. All the raw materials of the catalyst are rich in resource and low in price, and the catalyst can be recycled without inactivation and is very stable to air, water and heat.
Iridium(III)-Catalyzed Tandem Annulation of Pyridine-Substituted Anilines and α-Cl Ketones for Obtaining 2-Arylindoles
Cui, Xin-Feng,Qiao, Xin,Wang, He-Song,Huang, Guo-Sheng
, p. 13517 - 13528 (2020/12/15)
A facile and expeditious protocol for the synthesis of 2-arylindole compounds from readily available N-(2-pyridyl)anilines and commercially available α-Cl ketones through iridium-catalyzed C-H activation and cyclization is reported here. As a complementary approach to the conventional strategies for indole synthesis, the transformation exhibits powerful reactivity, tolerates a large number of functional groups, and proceeds with good to excellent yields under mild conditions, providing a straightforward method to obtain structurally diverse and valuable indole scaffolds. Furthermore, the reaction could be easily scaled up to gram scale.
SYNTHESIS OF HYPERVALENT IODINE REAGENTS WITH DIOXYGEN
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Paragraph 0178; 0182, (2019/01/15)
Methods of synthesis of hypervalent iodine reagents and methods for oxidation of organic compounds are disclosed.
Continuous-Flow Electrochemical Generator of Hypervalent Iodine Reagents: Synthetic Applications
Elsherbini, Mohamed,Winterson, Bethan,Alharbi, Haifa,Folgueiras-Amador, Ana A.,Génot, Célina,Wirth, Thomas
supporting information, p. 9811 - 9815 (2019/06/24)
An efficient and reliable electrochemical generator of hypervalent iodine reagents has been developed. In the anodic oxidation of iodoarenes to hypervalent iodine reagents under flow conditions, the use of electricity replaces hazardous and costly chemical oxidants. Unstable hypervalent iodine reagents can be prepared easily and coupled with different substrates to achieve oxidative transformations in high yields. The unstable, electrochemically generated reagents can also easily be transformed into classic bench-stable hypervalent iodine reagents through ligand exchange. The combination of electrochemical and flow-chemistry advantages largely improves the ecological footprint of the overall process compared to conventional approaches.
Regioselective three-component synthesis of 1,2-diarylindoles from cyclohexanones, α-hydroxyketones and anilines under transition-metal-free conditions
Li, Cheng,Xie, Yanjun,Xiao, Fuhong,Huang, Huawen,Deng, Guo-Jun
supporting information, p. 4079 - 4082 (2019/04/25)
A facile method for the one-pot synthesis of 1,2-diarylindoles under transition-metal-free conditions is described. Cyclohexanones were used as the aryl sources via the dehydrogenative aromatization process. One C-C and two C-N bonds were selectively formed via a domino reaction. This protocol provides a convenient approach for the construction of valuable bioactive 1,2-diarylindoles from readily available cyclohexanones, α-hydroxyketones and anilines.
Synthesis, characterisation, and reactivity of novel pseudocyclic hypervalent iodine reagents with heteroaryl carbonyl substituents
Qurban, Jihan,Elsherbini, Mohamed,Alharbi, Haifa,Wirth, Thomas
supporting information, p. 7998 - 8000 (2019/07/12)
Two new hypervalent iodine reagents containing furan and thiophene moieties in addition to a carbonyl group in the vicinity of the iodine atom were synthesised and characterised. The X-ray analysis of both compounds revealed a strong intramolecular contact between the carbonyl oxygen and the hypervalent iodine atom with tosylate as a counter ion. The two reagents showed a broad range of synthetic applications and proved to be versatile oxidizing agents.
Oxidase catalysis via aerobically generated hypervalent iodine intermediates
Maity, Asim,Hyun, Sung-Min,Powers, David C.
, p. 200 - 204 (2018/02/06)
The development of sustainable oxidation chemistry demands strategies to harness O'2 as a terminal oxidant. Oxidase catalysis, in which O'2 serves as a chemical oxidant without necessitating incorporation of oxygen into reaction products, would allow diverse substrate functionalization chemistry to be coupled to O'2 reduction. Direct O'2 utilization suffers from intrinsic challenges imposed by the triplet ground state of O'2 and the disparate electron inventories of four-electron O'2 reduction and two-electron substrate oxidation. Here, we generate hypervalent iodine reagents - a broadly useful class of selective two-electron oxidants - from O'2. This is achieved by intercepting reactive intermediates of aldehyde autoxidation to aerobically generate hypervalent iodine reagents for a broad array of substrate oxidation reactions. The use of aryl iodides as mediators of aerobic oxidation underpins an oxidase catalysis platform that couples substrate oxidation directly to O'2 reduction. We anticipate that aerobically generated hypervalent iodine reagents will expand the scope of aerobic oxidation chemistry in chemical synthesis.
A DEVELOPING AGENT PRECURSOR FOR LASER MARKABLE COMPOSITIONS
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Paragraph 0141, (2019/01/07)
The invention relates to novel laser markable compositions comprising developing agent precursors according to formula (I).
Facile synthesis of polysubstituted cyclopropanes using α-tosyloxyketones
Rana, Neena,Nain, Sonia,Kumar, Dinesh,Kumar, Ravi
, p. 505 - 507 (2018/02/09)
A facile synthesis of polysubstituted cyclopropanes (5) by the treatment of pyridinium ylides, generated in situ from pyridinium toslyates (2), with arylidenemalonitrile (4) is presented. Pyridinium toslyates (2) were obtained by reacting α-tosyloxyketone
