Glutamic acid, N-(diphenylmethylene)-, 1,1-dimethylethyl methyl ester

Base Information

• Chemical Name: Glutamic acid, N-(diphenylmethylene)-, 1,1-dimethylethyl methyl ester
• CAS No.: 226900-42-1
• Molecular Formula: C23H27NO4
• Molecular Weight: 381.472
• Mol file: 226900-42-1.mol

Synonyms:

Chemical Property of Glutamic acid, N-(diphenylmethylene)-, 1,1-dimethylethyl methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glutamic acid, N-(diphenylmethylene)-, 1,1-dimethylethyl methyl ester

There total 1 articles about Glutamic acid, N-(diphenylmethylene)-, 1,1-dimethylethyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(diphenylmethylene)glycine tert-butyl ester (81477-94-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 1-(tert-butyl) 5-methyl 2-[(diphenylmethylene)amino]pentanedioate (226900-42-1)

Guidance literature:

With 40 wtpercent of CsF loading on alumina; In tetrahydrofuran; at 20 ℃; for 1h; stereoselective reaction; Glovebox; Inert atmosphere;

DOI:10.1002/anie.201701789

Reference yield:

1-(tert-butyl) 5-methyl 2-[(diphenylmethylene)amino]pentanedioate (226900-42-1) → D-Glutamic acid (6893-26-1,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6)

Guidance literature:

With hydrogenchloride; In water; Overall yield = 89 %;

DOI:10.1021/cs400409d

Reference yield:

1-(tert-butyl) 5-methyl 2-[(diphenylmethylene)amino]pentanedioate (226900-42-1) → L-glutamic acid 1-tert-butyl ester 5-methyl ester (79640-72-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄

2: H₂ / Pd/C

With sodium tetrahydroborate; hydrogen; palladium on activated charcoal;

DOI:10.1016/S0040-4039(98)01067-3

upstream raw materials:

N-(diphenylmethylene)glycine tert-butyl ester

acrylic acid methyl ester

Downstream raw materials:

L-glutamic acid 1-tert-butyl ester 5-methyl ester

D-Glutamic acid

L-glutamic acid