1,3-Cyclohexanedicarboxylic acid, monoethyl ester, (1S,3R)-

Base Information

• Chemical Name: 1,3-Cyclohexanedicarboxylic acid, monoethyl ester, (1S,3R)-
• CAS No.: 227783-03-1
• Molecular Formula: C₁₀H₁₆O₄
• Molecular Weight: 200.235
• Mol file: 227783-03-1.mol

Synonyms:1,3-Cyclohexanedicarboxylic acid,monoethyl ester,(1S,3R);

Chemical Property of 1,3-Cyclohexanedicarboxylic acid, monoethyl ester, (1S,3R)-

Chemical Property:

• PSA: 66.43000
• LogP: 0.10580

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Cyclohexanedicarboxylic acid, monoethyl ester, (1S,3R)-

There total 1 articles about 1,3-Cyclohexanedicarboxylic acid, monoethyl ester, (1S,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis-1,3-Cyclohexanedicarboxylic acid diethyl ester (62059-56-7) → (1S,3R)-Cyclohexane-1,3-dicarboxylic acid monoethyl ester (227783-03-1)

Guidance literature:

With pH 7 buffer; Pseudomonas cepacia PS-30 lipase; In water;

DOI:10.1016/S0957-4166(99)00060-9

Reference yield:

(1S,3R)-Cyclohexane-1,3-dicarboxylic acid monoethyl ester (227783-03-1) + tert-butyl alcohol (75-65-0) → (1S,3R)-3-tert-Butoxycarbonylamino-cyclohexanecarboxylic acid ethyl ester

Guidance literature:

With diphenylphosphoranyl azide; triethylamine; In toluene; at 95 ℃;

DOI:10.1016/j.bmc.2005.01.033

Reference yield:

(1S,3R)-Cyclohexane-1,3-dicarboxylic acid monoethyl ester (227783-03-1) → (1S,3R)-3-((tert-butoxycarbonyl)amino)cyclo hexane-1-carboxylic acid (222530-34-9,218772-92-0,222530-33-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenylphosphoryl azide; triethylamine / toluene / 95 °C

2: aq. NaOH / tetrahydrofuran / 50 °C

With sodium hydroxide; diphenylphosphoranyl azide; triethylamine; In tetrahydrofuran; toluene; 1: Curtius rearrangement;

DOI:10.1016/j.bmc.2005.01.033

upstream raw materials:

cis-1,3-Cyclohexanedicarboxylic acid diethyl ester

Downstream raw materials:

(1S,3R)-3-((tert-butoxycarbonyl)amino)cyclo hexane-1-carboxylic acid