2-Amino-4-phenylthiazole-5-carboxylic acid

Base Information

Chemical Name:2-Amino-4-phenylthiazole-5-carboxylic acid
CAS No.:228413-61-4
Molecular Formula:C10H8N2O2S
Molecular Weight:220.252
Hs Code.:2934100090
DSSTox Substance ID:DTXSID80370713
Wikidata:Q82157853
ChEMBL ID:CHEMBL368799
Mol file:228413-61-4.mol

Synonyms:2-Amino-4-phenylthiazole-5-carboxylic acid;228413-61-4;2-amino-4-phenyl-1,3-thiazole-5-carboxylic Acid;2-AMINO-4-PHENYLTHIAZOLE-5-CARBOXYLICACID;CHEMBL368799;SCHEMBL2762916;DTXSID80370713;VNKAOZFTIGAIPR-UHFFFAOYSA-N;MFCD00665914;AKOS004118158;2-amino-4-phenylthiazol-5-ylcarboxylic acid;2-amino-4-phenyl-thiazol-5-ylcarboxylic acid;EN300-143773;F78910

Suppliers and Price of 2-Amino-4-phenylthiazole-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-AMINO-4-PHENYLTHIAZOLE-5-CARBOXYLIC ACID 95.00%
5MG
$ 503.88

Acrotein
2-Amino-4-phenylthiazole-5-carboxylicacid 97%
1g
$ 330.00

Total 5 raw suppliers

Chemical Property of 2-Amino-4-phenylthiazole-5-carboxylic acid

Chemical Property:

PSA：104.45000
LogP:2.67170
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:220.03064868
Heavy Atom Count:15
Complexity:244

Purity/Quality:

97% ^*data from raw suppliers

2-AMINO-4-PHENYLTHIAZOLE-5-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(SC(=N2)N)C(=O)O

Technology Process of 2-Amino-4-phenylthiazole-5-carboxylic acid

There total 5 articles about 2-Amino-4-phenylthiazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 893652-36-3
methyl 2-amino-4-phenyl-1,3-thiazole-5-carboxylate

: 228413-61-4
2-amino-4-phenylthiazole-5-carboxylic acid

Guidance literature:: With lithium hydroxide; In methanol; water; at 20 ℃; for 8h;
DOI:10.1021/acs.joc.9b01722

Reference yield:

: 64399-23-1
ethyl 4-phenyl-2-aminothiazole-5-carboxylate

: 228413-61-4
2-amino-4-phenylthiazole-5-carboxylic acid

Guidance literature:: ethyl 4-phenyl-2-aminothiazole-5-carboxylate; With sodium hydroxide; In ethanol; water; at 20 ℃; for 72h;

With hydrogenchloride; In water;

Reference yield:

: 86971-60-0
(Z)-3-amino-3-phenylacrylic acid methyl ester

: 228413-61-4
2-amino-4-phenylthiazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.08 h / 20 °C

2: lithium hydroxide / methanol; water / 8 h / 20 °C

With N-Bromosuccinimide; lithium hydroxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.joc.9b01722