64399-23-1

Basic information

• Product Name: Ethyl 2-amino-4-phenyl-5-thiazolecarboxylate
• Synonyms: BUTTPARK 16\03-22;AURORA 19935;ETHYL 2-AMINO-4-PHENYL-5-THIAZOLECARBOXYLATE;ETHYL 2-AMINO-4-PHENYLTHIAZOLE-5-CARBOXYLATE;ETHYL 2-AMINO-4-METHYLTHIAZOLE-5-CARBOXYLATE HYDROCHLORIDE;ETHYL 2-AMINO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE HYDROCHLORIDE;ETHYL 2-AMINO-4-METHYLTHIAZOLE-5-CARBOXYLATE HCL;AKOS BBS-00007970
• CAS NO: 64399-23-1
• Molecular Formula: C₁₂H₁₂N₂O₂S
• Molecular Weight: 248.31
• Product Categories: Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Thiazoles
• Mol File: 64399-23-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 169-173 °C(lit.)
• Boiling Point: 449.1 °C at 760 mmHg
• Flash Point: 225.4 °C
• Appearance: Light brown/Crystalline Powder
• Density: 1.2701 (rough estimate)
• Vapor Pressure: 2.94E-08mmHg at 25°C
• Refractive Index: 1.5950 (estimate)
• Solubility: soluble in Dimethylformamide
• PKA: 2.51±0.10(Predicted)
• BRN: 222259
• CAS DataBase Reference: Ethyl 2-amino-4-phenyl-5-thiazolecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-amino-4-phenyl-5-thiazolecarboxylate(64399-23-1)
• EPA Substance Registry System: Ethyl 2-amino-4-phenyl-5-thiazolecarboxylate(64399-23-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 64399-23-1(Hazardous Substances Data)

Usage

Chemical Properties

light brown crystalline powder

InChI:InChI=1/C12H12N2O2S/c1-2-16-11(15)10-9(14-12(13)17-10)8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H2,13,14)

Upstream product

• 41381-97-9 ethyl 2-chloro-3-oxo-3-phenylpropionate 
• 17356-08-0 thiourea 
• 1147550-11-5 ammonium thiocyanate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 55919-47-6 ethyl 2-bromo-3-oxo-3-phenylpropionate 
• 34320-89-3 2-iodo-3-oxo-3-phenyl-propionic acid ethyl ester 
• 27126-76-7 [hydroxy(tosyloxy)iodo]benzene 

Downstream Products

• 228413-61-4 2-amino-4-phenylthiazole-5-carboxylic acid 
• 177328-30-2 ethyl-2-bromo-4-phenyl-1,3-thiazol-5-carboxylate 
• 376349-01-8 ethyl 2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-4-phenyl-1,3-thiazole-5-carboxylate 
• 860650-74-4 2-amino-4-phenyl-thiazole-5-carboxylic acid hydrazide 
• 74476-47-4 2-chloro-4-phenylthiazole-5-carboxylic acid ethyl ester 
• 1205603-16-2 2-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-4-phenyl-thiazole-5-carboxylic acid ethyl ester 
• 1232234-38-6 2-(5-dimethoxymethyl-2-nitro-phenylamino)-4-phenyl-thiazole-5-carboxylic acid ethyl ester 
• 302963-98-0 ethyl 2-((tert-butoxycarbonyl)amino)-4-phenylthiazole-5-carboxylate 
• 1232234-40-0 2-[5-(4-methyl-piperazin-1-ylmethyl)-2-nitro-phenylamino]-4-phenyl-thiazole-5-carboxylic acid ethyl ester 
• 1232234-41-1 2-[2-amino-5-(4-methyl-piperazin-1-ylmethyl)-phenylamino]-4-phenyl-thiazole-5-carboxylic acid ethyl ester 
• 1232234-43-3 2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-4-phenyl-thiazole-5-carboxylic acid 
• 1232233-71-4 2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-4-phenyl-thiazole-5-carboxylic acid amide 
• 1232234-39-7 2-(5-formyl-2-nitro-phenylamino)-4-phenyl-thiazole-5-carboxylic acid ethyl ester 
• 957051-06-8 2-benzoylamino-4-phenylthiazole-5-carboxylic acid 

Relevant articles and documents

Visible-light-promoted aerobic metal-free aminothiocyanation of activated ketones

A direct, redox-neutral, highly atom-economical and metal-free aerobic method for the synthesis of multi-substituted olefins via simply coupling ammonium thiocyanate with activated ketones is described. A series of multi-substituted olefins could be easil

I2/CuO-catalyzed tandem cyclization strategy for one-pot synthesis of substituted 2-aminothiozole from easily available aromatic ketones/α,β-unsaturated ketones and thiourea

A concise and efficient one-pot process from easily available methyl ketones/unsaturated methyl ketones and thiourea was developed for the synthesis of 2-aminothiazoles under the media of I2/CuO. The method can highly stereoselectivity obtain the E-isomers of 4-ethenyl-2-aminothiazoles (5a-f). All these target molecules were characterized by NMR, HRMS and IR spectra. Furthermore, the target compounds 3c and 5b were further determined by X-ray crystallographic analysis.

Aqueous-phase one-pot synthesis of 2-aminothiazole- or 2-aminoselenazole-5- carboxylates from β-keto esters, thiourea or selenourea, and N-bromosuccinimide under supramolecular catalysis

2-Amino-4-alkyl- and 2-amino-4-arylthiazole-5-carboxylates and their selenazole analogues were synthesized by α-halogenation of β-keto esters with N-bromosuccinimide, followed by cyclization with thiourea or selenourea, respectively, in the presence of β-