Acetamide, N-[2-[(2-aminophenyl)ethynyl]phenyl]-2,2,2-trifluoro-

Base Information

Chemical Name:Acetamide, N-[2-[(2-aminophenyl)ethynyl]phenyl]-2,2,2-trifluoro-
CAS No.:228575-98-2
Molecular Formula:C16H11F3N2O
Molecular Weight:304.271
Hs Code.:
DSSTox Substance ID:DTXSID70455189
Nikkaji Number:J1.144.346J
Wikidata:Q82277096

Synonyms:Acetamide, N-[2-[(2-aminophenyl)ethynyl]phenyl]-2,2,2-trifluoro-;228575-98-2;DTXSID70455189;KKHNMQOTYMDOJI-UHFFFAOYSA-N;N-[2-(2-Aminophenylethynyl)phenyl]trifluoroacetamide

Suppliers and Price of Acetamide, N-[2-[(2-aminophenyl)ethynyl]phenyl]-2,2,2-trifluoro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of Acetamide, N-[2-[(2-aminophenyl)ethynyl]phenyl]-2,2,2-trifluoro-

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:304.08234746
Heavy Atom Count:22
Complexity:463

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C#CC2=CC=CC=C2NC(=O)C(F)(F)F)N

Technology Process of Acetamide, N-[2-[(2-aminophenyl)ethynyl]phenyl]-2,2,2-trifluoro-

There total 2 articles about Acetamide, N-[2-[(2-aminophenyl)ethynyl]phenyl]-2,2,2-trifluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 52670-38-9
2-ethynylaniline

: 143321-89-5
2,2,2-trifluoro-N-(2-iodophenyl)acetamide

: 228575-98-2
N-{2-[(2-aminophenyl)ethynyl]phenyl}-2,2,2-trifluoroacetamide

Guidance literature:: DOI:10.3762/bjoc.14.218

Reference yield:

: 52670-38-9
2-ethynylaniline

: 228575-98-2
N-{2-[(2-aminophenyl)ethynyl]phenyl}-2,2,2-trifluoroacetamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.06.079

Reference yield: 96.0%

: 586-78-7
para-nitrophenyl bromide

: 228575-98-2
N-{2-[(2-aminophenyl)ethynyl]phenyl}-2,2,2-trifluoroacetamide

: 12-(4-nitrophenyl)indolo[1,2-c]quinazolin-6(5H)-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In acetonitrile; at 100 ℃; for 25h; Inert atmosphere;
DOI:10.1055/s-0036-1589158