143321-89-5Relevant articles and documents
Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease
Benek, Ondrej,Soukup, Ondrej,Pasdiorova, Marketa,Hroch, Lukas,Sepsova, Vendula,Jost, Petr,Hrabinova, Martina,Jun, Daniel,Kuca, Kamil,Zala, Dominykas,Ramsay, Rona R.,Marco-Contelles, José,Musilek, Kamil
, p. 1264 - 1269 (2016)
Novel indolotacrine analogues were designed, synthesized, and evaluated as potential drugs for the treatment of Alzheimer's disease. By using a multitarget-directed ligand approach, compounds were designed to act simultaneously as cholinesterase (ChE) and
Biosynthesis of [14C]-11-De-O-Methyltomaymycin, a Precursor of Radiolabelled Antibody Drug Conjugates
Aubert, Catherine,Lavisse, Mélanie,Roy, Sebastien
, p. 2424 - 2429 (2021/06/09)
Antibody drug conjugates (ADCs) are one of the most promising technologies to treat cancer as they combine the specificity of an antibody with the high potency of a cytotoxic molecule such as tomaymycin derivatives, which are DNA-interactive antitumor ant
Disparate Catalytic Scaffolds for Atroposelective Cyclodehydration
Kwon, Yongseok,Li, Junqi,Reid, Jolene P.,Crawford, Jennifer M.,Jacob, Roxane,Sigman, Matthew S.,Toste, F. Dean,Miller, Scott J.
supporting information, p. 6698 - 6705 (2019/05/06)
Catalysts that control stereochemistry are prized tools in chemical synthesis. When an effective catalyst is found, it is often explored for other types of reactions, frequently under the auspices of different mechanisms. As successes mount, a unique cata