3-nitro-6-hydroxy-2,4-dimethylpyridine

Base Information

• Chemical Name: 3-nitro-6-hydroxy-2,4-dimethylpyridine
• CAS No.: 22934-24-3
• Molecular Formula: C7H8N2O3
• Molecular Weight: 168.152
• Mol file: 22934-24-3.mol

Synonyms:3-nitro-6-hydroxy-2,4-dimethylpyridine;6-Hydroxy-3-nitro-2,4-dimethyl-pyridin;6-Hydroxy-3-nitro-2,4-lutidin;4,6-dimethyl-5-nitro-pyridin-2-ol;

Chemical Property of 3-nitro-6-hydroxy-2,4-dimethylpyridine

Chemical Property:

• Melting Point: 251 °C
• Boiling Point: 323.5±35.0 °C(Predicted)
• PKA: 8.20±0.10(Predicted)
• PSA: 78.94000
• Density: 1.29±0.1 g/cm3(Predicted)
• LogP: 1.83540

Purity/Quality:

99% ^*data from raw suppliers

3-Nitro-6-hydroxy-2,4-dimethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-nitro-6-hydroxy-2,4-dimethylpyridine

There total 8 articles about 3-nitro-6-hydroxy-2,4-dimethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

3-Cyano-4,6-dimethyl-2(1H)-pyridon (769-28-8) → 4,6-dimethyl-5-nitropyridin-2-one (22934-24-3)

Guidance literature:

3-Cyano-4,6-dimethyl-2(1H)-pyridon; With potassium nitrate;

With sulfuric acid;

DOI:10.3390/molecules25071682

Reference yield:

3-Nitro-6-amino-2,4-dimethyl-pyridin (22934-22-1) → 5-nitro-6-hydroxy-2,4-dimethylpyridine (22934-13-0) + 3-nitro-6-hydroxy-2,4-dimethylpyridine (22934-24-3)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 0 - 20 ℃;

Reference yield:

2-Amino-4,6-dimethylpyridine (5407-87-4) → 5-nitro-6-hydroxy-2,4-dimethylpyridine (22934-13-0) + 3-nitro-6-hydroxy-2,4-dimethylpyridine (22934-24-3)

Guidance literature:

With sulfuric acid; nitric acid;

upstream raw materials:

2-hydroxy-4,6-dimethyl-5-nitro-nicotinic acid

2-Amino-4,6-dimethylpyridine

3-Nitro-6-amino-2,4-dimethyl-pyridin

3-Cyano-4,6-dimethyl-2(1H)-pyridon

Refernces

• 1、 Babaev, Eugene V.,Rybakov, Victor B.. "Phenacylation of 6-methyl-beta-nitropyridin-2-ones and further heterocyclization of products". . . Retrieved 2020/04/17.
• 2、 Sawanishi, Hiroyuki,Tajima, Kayoko,Tsuchiya, Takashi. "Studies on Diazepines. XXVIII. Syntheses of 5H-1,3-Diazepines and 2H-1,4-Diazepines from 3-Azidopyridines". . p. 4101 - 4109. Retrieved 2007/10/02.