3-(2-Methoxyphenyl)propanoyl chloride

Base Information

• Chemical Name: 3-(2-Methoxyphenyl)propanoyl chloride
• CAS No.: 22955-75-5
• Molecular Formula: C10H11ClO2
• Molecular Weight: 198.649
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID401297521
• Mol file: 22955-75-5.mol

Synonyms:3-(2-methoxyphenyl)propanoyl chloride;22955-75-5;3-(2-methoxy-phenyl)propionyl chloride;3-(2-Methoxyphenyl)propionyl chloride;SCHEMBL4743195;2-Methoxybenzenepropanoyl chloride;YEGXZBYGDXGWJU-UHFFFAOYSA-N;DTXSID401297521;AKOS006275831;3-(2-methoxy-phenyl)-propionyl chloride

Chemical Property of 3-(2-Methoxyphenyl)propanoyl chloride

Chemical Property:

• PSA: 26.30000
• LogP: 2.39320
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 198.0447573
• Heavy Atom Count: 13
• Complexity: 170

Purity/Quality:

99% ^*data from raw suppliers

3-(2-Methoxy-phenyl)propionylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1CCC(=O)Cl

Technology Process of 3-(2-Methoxyphenyl)propanoyl chloride

There total 10 articles about 3-(2-Methoxyphenyl)propanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methoxy-benzenepropanoic acid (6342-77-4) → 3-(2-methoxyphenyl)propionyl chloride (22955-75-5)

Guidance literature:

With thionyl chloride;

DOI:10.1002/recl.19931120212

Reference yield:

ortho-anisaldehyde (135-02-4) → 3-(2-methoxyphenyl)propionyl chloride (22955-75-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / piperidine, pyridine / 4 h / 85 - 110 °C

2: 96 percent / H₂ / 10percent Pd/C / aq. ethanol / 2660 Torr

3: 94 percent / SOCl₂ / benzene / 3 h / Heating

With piperidine; pyridine; thionyl chloride; hydrogen; palladium on activated charcoal; In ethanol; benzene;

DOI:10.1021/jm00072a008

Reference yield:

2-methoxycinnamic acid (1011-54-7) → 3-(2-methoxyphenyl)propionyl chloride (22955-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / H₂ / 10percent Pd/C / aq. ethanol / 2660 Torr

2: 94 percent / SOCl₂ / benzene / 3 h / Heating

With thionyl chloride; hydrogen; palladium on activated charcoal; In ethanol; benzene;

DOI:10.1021/jm00072a008

upstream raw materials:

2-methoxy-benzenepropanoic acid

2-methoxycinnamic acid

ortho-anisaldehyde

2-methoxyphenylacetic acid

Downstream raw materials:

5-(2-methoxy-phenyl)-2-methyl-3-oxo-valeric acid ethyl ester

3-(2-methoxyphenyl)propanal

3-(2-methoxyphenyl)-1-(4-methoxyphenyl)propan-1-one

1-diazo-4-(2'-methoxyphenyl)butan-2-one