Adenosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-

Base Information

• Chemical Name: Adenosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-
• CAS No.: 231957-26-9
• Molecular Formula: C33H33N5O7
• Molecular Weight: 611.64400
• Mol file: 231957-26-9.mol

Synonyms:Adenosine,N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl];

Chemical Property of Adenosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-

Chemical Property:

• PSA: 153.57000
• LogP: 4.07930

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Adenosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-

There total 6 articles about Adenosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N6-acetyl-adenosine (16265-37-5) → N6-acetyl-5'-O-(4,4'-dimethoxytrityl)adenosine (231957-26-9)

Guidance literature:

With pyridine; at 20 ℃; for 1h;

DOI:10.1002/1522-2675(20011219)84:12<3773::AID-HLCA3773>3.0.CO;2-E

Reference yield:

adenosine (58-61-7) → N6-acetyl-5'-O-(4,4'-dimethoxytrityl)adenosine (231957-26-9)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 14 h / 20 °C

2: pyridine / acetonitrile / 1 h / 4 °C

3: 91 g / AcOH / methanol / 48 h / -20 °C

4: 75 percent / pyridine / 1 h / 20 °C

With pyridine; acetic acid; In methanol; acetonitrile;

DOI:10.1002/1522-2675(20011219)84:12<3773::AID-HLCA3773>3.0.CO;2-E

Reference yield:

O2',O3',O5'-tris-trimethylsilanyl-adenosine (10457-15-5) → N6-acetyl-5'-O-(4,4'-dimethoxytrityl)adenosine (231957-26-9)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / acetonitrile / 1 h / 4 °C

2: 91 g / AcOH / methanol / 48 h / -20 °C

3: 75 percent / pyridine / 1 h / 20 °C

With pyridine; acetic acid; In methanol; acetonitrile;

DOI:10.1002/1522-2675(20011219)84:12<3773::AID-HLCA3773>3.0.CO;2-E

upstream raw materials:

4,4'-dimethoxytrityl chloride

N₆-acetyl-adenosine

O^2'_,O3'_,O5'-tris-trimethylsilanyl-adenosine

adenosine

Downstream raw materials:

N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-acetamide

N⁶-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine

N⁶-acetyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-{[(triisopropylsilyl)oxy]methyl}adenosine

N-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[(R)-1-(2-nitro-phenyl)-ethoxymethoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-acetamide