Carbonic acid, chloromethyl 4-chloro-2-[[2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3(2H)-yl] methyl]phenyl ester

Base Information

• Chemical Name: Carbonic acid, chloromethyl 4-chloro-2-[[2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3(2H)-yl] methyl]phenyl ester
• CAS No.: 233676-40-9
• Molecular Formula: C18H11Cl2F3N2O5
• Molecular Weight: 463.197
• Mol file: 233676-40-9.mol

Synonyms:

Chemical Property of Carbonic acid, chloromethyl 4-chloro-2-[[2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3(2H)-yl] methyl]phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbonic acid, chloromethyl 4-chloro-2-[[2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3(2H)-yl] methyl]phenyl ester

There total 1 articles about Carbonic acid, chloromethyl 4-chloro-2-[[2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3(2H)-yl] methyl]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

carbonochloridic acid, chloromethyl ester (22128-62-7) + 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)-phenyl]-1,3,4-oxadiazol-2(3H)-one (202821-81-6) → 3-[(5-Chloro-2-[[(chloromethyl)oxy]carbonyloxy]phenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3 H)-one (233676-40-9)

Guidance literature:

With pyridine; In dichloromethane;

Reference yield:

3-[(5-Chloro-2-[[(chloromethyl)oxy]carbonyloxy]phenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3 H)-one (233676-40-9) → 3-[(5-Chloro-2-[[[(phosphonooxy)methyl]oxy]carbonyloxy]-phenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one

Guidance literature:

Multi-step reaction with 3 steps

1: NaI / acetone / Heating

2: benzene / Heating

3: H₂ / PtO₂ / ethyl acetate / 2068.59 Torr

With hydrogen; sodium iodide; platinum(IV) oxide; In ethyl acetate; acetone; benzene; 1: Finkelstein reaction;

DOI:10.1016/S0960-894X(03)00296-8

Reference yield:

3-[(5-Chloro-2-[[(chloromethyl)oxy]carbonyloxy]phenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3 H)-one (233676-40-9) → carbonic acid bis-benzyloxy-phosphoryloxymethyl ester 4-chloro-2-[2-oxo-5-(4-trifluoromethyl-phenyl)-[1,3,4]oxadiazol-3-ylmethyl]-phenyl ester (233676-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI / acetone / Heating

2: benzene / Heating

With sodium iodide; In acetone; benzene; 1: Finkelstein reaction;

DOI:10.1016/S0960-894X(03)00296-8

upstream raw materials:

carbonochloridic acid, chloromethyl ester

3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)-phenyl]-1,3,4-oxadiazol-2(3H)-one

Downstream raw materials:

carbonic acid bis-benzyloxy-phosphoryloxymethyl ester 4-chloro-2-[2-oxo-5-(4-trifluoromethyl-phenyl)-[1,3,4]oxadiazol-3-ylmethyl]-phenyl ester