Chemical Property of 3-(5-Chloro-2-hydroxybenzyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Boiling Point:443.965oC at 760 mmHg
- PKA:9.27±0.43(Predicted)
- Flash Point:222.302oC
- PSA：68.26000
- Density:1.516g/cm3
- LogP:3.92940
- Storage Temp.:Store at RT
- Solubility.:DMSO: soluble20mg/mL, clear (warmed)
- XLogP3:4.3
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:3
- Exact Mass:370.0332044
- Heavy Atom Count:25
- Complexity:535
- Purity/Quality:
-
99%, *data from raw suppliers
BMS 191011 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:T
- Statements:
25
- Safety Statements:
45
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC(=CC=C1C2=NN(C(=O)O2)CC3=C(C=CC(=C3)Cl)O)C(F)(F)F
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Description
BMS 191011 is an activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels that increases maximum potassium current to 126% of control in X. laevis oocytes expressing human KCa1.1 channels when used at a concentration of 1 μM. In vivo, BMS 191011 (10-100 μg/kg, i.v.) increases the diameter of retinal arterioles without affecting blood pressure or heart rate in rats, an effect that is reversed by the KCa1.1 channel blocker iberiotoxin .
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Uses
BMS 191011, is a potent opener of the large-conductance, Ca2+-activated potassium (maxi-K) channel. It has also shown neuroprotective properties in two distinct animal models of stroke- MCAO in the SHR rat and a normotensive model of focal stroke.
