Phenazine-1,6-dicarboxylic acid dimethyl ester

Base Information

• Chemical Name: Phenazine-1,6-dicarboxylic acid dimethyl ester
• CAS No.: 23531-24-0
• Molecular Formula: C16H12N2O4
• Molecular Weight: 296.27700
• Mol file: 23531-24-0.mol

Synonyms:Phenazin-1,6-dicarbonsaeuredimethylester;1,6-dicarbomethoxy-phenazine;Phenazin-1,6-dicarbonsaeure-dimethylester;1,6-dicarbomethoxyphenazine;Phenazine-1,6-dicarboxylic acid dimethyl ester;phencomycin methyl ester;

Chemical Property of Phenazine-1,6-dicarboxylic acid dimethyl ester

Chemical Property:

• Boiling Point: 482.3±15.0 °C(Predicted)
• PKA: -2.24±0.30(Predicted)
• PSA: 78.38000
• Density: 1.347±0.06 g/cm3(Predicted)
• LogP: 2.35620

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenazine-1,6-dicarboxylic acid dimethyl ester

There total 16 articles about Phenazine-1,6-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + phenazine-1,6-dicarboxylic acid (23462-25-1) → 1,6-dicarbomethoxy-phenazine (23531-24-0)

Guidance literature:

In diethyl ether;

Reference yield:

C16H15BrN2O4 → 1,6-dicarbomethoxy-phenazine (23531-24-0)

Guidance literature:

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃;

DOI:10.1016/S0040-4039(99)02061-4

Reference yield:

2-bromo-3-nitro-benzoic acid methyl ester (5337-09-7) → 1,6-dicarbomethoxy-phenazine (23531-24-0)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium(II) acetate; BINAP; Cs₂CO₃ / toluene / 100 °C

2: H₂ / Pd-C / ethyl acetate

3: palladium(II) acetate; BINAP; Cs₂CO₃ / toluene / 100 °C

With hydrogen; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium on activated charcoal; In ethyl acetate; toluene; 1: Arylation / 2: Catalytic hydrogenation / 3: Cyclization;

DOI:10.1016/S0040-4039(99)02061-4

upstream raw materials:

diazomethane

phenazine-1,6-dicarboxylic acid

methanol

phenazine-1,6-dicarbonyl chloride