1H-Pyrrole-2,4-dicarboxaldehyde

Base Information

• Chemical Name: 1H-Pyrrole-2,4-dicarboxaldehyde
• CAS No.: 23999-91-9
• Molecular Formula: C6H5NO2
• Molecular Weight: 123.111
• Hs Code.: 2933990090
• Mol file: 23999-91-9.mol

Synonyms:2,4-DIFORMYLPYRROLE;pyrrole-2,4-dicarboxaldehyde;Pyrrol-2,4-dicarbaldehyd;1H-pyrrole-2,4-dicarboxaldehyde;Pyrrol-2,4-dicarboxaldehyd;2,4-Pyrroldicarboxaldehyd;pyrrole-2,4-dicarbaldehyde;

Chemical Property of 1H-Pyrrole-2,4-dicarboxaldehyde

Chemical Property:

• PSA: 49.93000
• LogP: 0.63970

Purity/Quality:

99% ^*data from raw suppliers

1H-PYRROLE-2,4-DICARBOXALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-2,4-dicarboxaldehyde

There total 6 articles about 1H-Pyrrole-2,4-dicarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

pyrrole-2,4-dicarbonitrile (74023-87-3) → 1H-pyrrole-2,4-dicarboxaldehyde (23999-91-9) + 5-formyl-1H-pyrrole-3-carbonitrile (40740-39-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2.5h;

Reference yield: 70.0%

3,5-dichloro-1H-pyrrole-2,4-dicarboxaldehyde (152420-76-3) → 1H-pyrrole-2,4-dicarboxaldehyde (23999-91-9)

Guidance literature:

With 10% palladium on carbon; hydrogen; triethylamine; In methanol; at 23 ℃; for 4h; under 760.051 Torr;

DOI:10.1016/j.tet.2010.06.006

Reference yield: 56.0%

pyrrole-2,4-dicarbonitrile (74023-87-3) → 1H-pyrrole-2,4-dicarboxaldehyde (23999-91-9)

Guidance literature:

With formic acid; Ra-Ni alloy; for 1.5h; Heating;

upstream raw materials:

Dichloromethyl methyl ether

N-((1H-pyrrol-2-yl)methylene)-N-methylmethanaminium hydrogen chloride

pyrrole-2,4-dicarbonitrile

3,5-dichloro-1H-pyrrole-2,4-dicarboxaldehyde

Downstream raw materials:

2-((3-methoxy-5-phenyl-2H-pyrrol-2-ylidene)methyl)-3,5-dimethyl-1H-pyrrole

obatoclax

2,4-dimethyl-1H-pyrrole

Refernces

• 1、 Muchowski, Joseph M.,Hess, Petr. "LITHIATION OF THE DIMER OF 3-BROMO-6-DIMETHYLAMINO-1-AZAFULVENE. EFFICACIOUS SYNTHESIS OF 4-MONO- AND 4,5-DISUBSTITUTED PYRROLE-2-CARBOXALDEHYDES.". . p. 3215 - 3218. Retrieved 2007/10/02.
• 2、 Barnett, Graham H.,Anderson, Hugh J.,Loader, Charles, E.. "Pyrrole chemistry. XXI. Synthetic approaches to cyanopyrroles". . p. 409 - 411. Retrieved 2007/10/02.