5-Methyl-2-(p-tolylamino)benzoic acid

Base Information

• Chemical Name: 5-Methyl-2-(p-tolylamino)benzoic acid
• CAS No.: 24173-43-1
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.29
• European Community (EC) Number: 878-757-9
• Nikkaji Number: J866.255J
• Mol file: 24173-43-1.mol

Synonyms:5-Methyl-2-(p-tolylamino)benzoic acid;24173-43-1;2-(p-Tolylamino)-5-methylbenzoic acid;5-methyl-2-(4-methylanilino)benzoic acid;SCHEMBL9593414;MFCD19497412;AKOS012845987;CS-0201669;M3165;G72231;5-methyl-2-[(4-methylphenyl)amino]benzoic acid;Benzoic acid, 5-methyl-2-[(4-methylphenyl)amino]-

Chemical Property of 5-Methyl-2-(p-tolylamino)benzoic acid

Chemical Property:

• XLogP3: 5.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 241.110278721
• Heavy Atom Count: 18
• Complexity: 284

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NC2=C(C=C(C=C2)C)C(=O)O

Technology Process of 5-Methyl-2-(p-tolylamino)benzoic acid

There total 6 articles about 5-Methyl-2-(p-tolylamino)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-methyl-1-(p-tolyl)indoline-2,3-dione → 2-(N-(4-methylphenyl)amino)-5-methylbenzoic acid (24173-43-1)

Guidance literature:

5-methyl-1-(p-tolyl)indoline-2,3-dione; With water; sodium hydroxide; at 20 ℃; for 4h;

With dihydrogen peroxide; In water;

DOI:10.2174/157017810790796354

Reference yield: 85.0%

p-toluidine (106-49-0,12221-03-3) → 2-(N-(4-methylphenyl)amino)-5-methylbenzoic acid (24173-43-1)

Guidance literature:

With copper; potassium carbonate; In pentan-1-ol; for 3h; Reflux;

DOI:10.1021/jo401683r

Reference yield: 5.6%

2-Amino-5-methylbenzoic acid (2941-78-8) + para-bromotoluene (106-38-7) → 2-(N-(4-methylphenyl)amino)-5-methylbenzoic acid (24173-43-1)

Guidance literature:

With copper; sodium carbonate; In butan-1-ol; for 24h; Heating;

DOI:10.1271/bbb.61.1121

upstream raw materials:

2-Amino-5-methylbenzoic acid

para-bromotoluene

p-toluidine

2-bromo-5-methylbenzoic acid

Downstream raw materials:

9-Amino-2,7-dimethylacridine

methyl 2-(N-(4-methylphenyl)amino)-5-methylbenzoate

C₁₆H₁₉NO

5-methyl-2-(methyl(p-tolyl)amino)benzaldehyde