methyl 2-(N-(4-methylphenyl)amino)-5-methylbenzoate

Base Information

• Chemical Name: methyl 2-(N-(4-methylphenyl)amino)-5-methylbenzoate
• CAS No.: 1240314-96-8
• Molecular Formula: C₁₆H₁₇NO₂
• Molecular Weight: 255.316
• Mol file: 1240314-96-8.mol

Synonyms:

Chemical Property of methyl 2-(N-(4-methylphenyl)amino)-5-methylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(N-(4-methylphenyl)amino)-5-methylbenzoate

There total 4 articles about methyl 2-(N-(4-methylphenyl)amino)-5-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

4-tolyl iodide (624-31-7) + 2-amino-5-methylbenzoic acid methyl ester (18595-16-9) → methyl 2-(N-(4-methylphenyl)amino)-5-methylbenzoate (1240314-96-8)

Guidance literature:

With copper; potassium carbonate; at 180 ℃; for 10h;

DOI:10.1021/acs.inorgchem.0c03274

Reference yield: 92.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-(N-(4-methylphenyl)amino)-5-methylbenzoic acid (24173-43-1) → methyl 2-(N-(4-methylphenyl)amino)-5-methylbenzoate (1240314-96-8) + methyl 2-(N-methyl-N-(4-methylphenyl)amino)-5-methylbenzoate

Guidance literature:

In diethyl ether; at 20 ℃;

DOI:10.2174/157017810790796354

Reference yield: 72.6%

para-bromotoluene (106-38-7) + 2-amino-5-methylbenzoic acid methyl ester (18595-16-9) → methyl 2-(N-(4-methylphenyl)amino)-5-methylbenzoate (1240314-96-8)

Guidance literature:

With tri-tert-butyl phosphine; palladium diacetate; caesium carbonate; In toluene; for 18.5h; Inert atmosphere; Reflux;

DOI:10.1039/c5dt01636c

upstream raw materials:

diazomethane

2-(N-(4-methylphenyl)amino)-5-methylbenzoic acid

p-toluidine

methyl 2-bromo-5-methylbenzoate

Downstream raw materials:

N-methoxy-5-methyl-2-(methyl(p-tolyl)amino)benzamide

N-methyl-N-(4-methylphenyl)-5-methylanthranilic acid