6,7-Dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline

Base Information

Chemical Name:6,7-Dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline
CAS No.:24456-60-8
Molecular Formula:C12H15NO2S
Molecular Weight:237.323
Hs Code.:
DSSTox Substance ID:DTXSID201216705

Synonyms:24456-60-8;6,7-dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline;SCHEMBL11490121;DTXSID201216705;3,4-Dihydro-6,7-dimethoxy-1-(methylthio)isoquinoline

Suppliers and Price of 6,7-Dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6,7-Dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline

Chemical Property:

Vapor Pressure:0mmHg at 25°C
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:237.08234989
Heavy Atom Count:16
Complexity:270

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)CCN=C2SC)OC

Technology Process of 6,7-Dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline

There total 1 articles about 6,7-Dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 493-49-2
6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one

: 24456-60-8
6,7-dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / phosphoruspentasulphide / pyridine / 2.5 h / Heating

2: 60 percent / CH₂Cl₂ / 2 h / Heating

With phosphorous (V) sulfide; In pyridine; dichloromethane;
DOI:10.1016/0040-4020(80)80195-5

Reference yield: 93.0%

: 24456-60-8
6,7-dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline

: 98-80-6
phenylboronic acid

: 10133-76-3
3,4-dihydro-6,7-dimethoxy-1-phenylisoquinoline hydrochloride

Guidance literature:: 6,7-dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline; phenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; In tetrahydrofuran; Inert atmosphere; Reflux;

With hydrogenchloride;
DOI:10.1007/s00706-015-1564-y

Reference yield: 92.0%

: 24456-60-8
6,7-dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 15547-57-6
1-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; In tetrahydrofuran; Inert atmosphere; Reflux;
DOI:10.1007/s00706-015-1564-y