493-49-2

Basic information

• Product Name: 6,7-DIMETHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
• Synonyms: 6,7-DIMETHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE;AKOS 233-63;3,4-Dihydro-6,7-dimethoxy-1(2H)-isoquinolinone;3,4-Dihydro-6,7-dimethoxyisoquinolin-1(2H)-one;6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-one;Corydaldine;6,7-DiMethoxy-3,4-dihydroisoquinolin-1(2H)-one
• CAS NO: 493-49-2
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.23
• Mol File: 493-49-2.mol
• Article Data: 34

Chemical Properties

• Melting Point: 175°
• Boiling Point: 346.25°C (rough estimate)
• Flash Point: 237.3°C
• Appearance: /
• Density: 1.1878 (rough estimate)
• Vapor Pressure: 5.83E-09mmHg at 25°C
• Refractive Index: 1.5100 (estimate)
• Storage Temp.: 2-8°C
• PKA: 14.23±0.20(Predicted)
• CAS DataBase Reference: 6,7-DIMETHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DIMETHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(493-49-2)
• EPA Substance Registry System: 6,7-DIMETHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(493-49-2)

Safety Data

• Hazardous Substances Data: 493-49-2(Hazardous Substances Data)

Usage

General Description

6,7-Dimethoxy-3,4-dihydro-2H-isoquinolin-1-one is a chemical compound with the molecular formula C11H13NO3. It is a derivative of isoquinolinone and contains two methoxy groups on the 6 and 7 positions. 6,7-DIMETHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE has been studied for its potential pharmacological properties, particularly its effects on the central nervous system. It has been investigated as a potential drug candidate for various neurological disorders and as an analgesic. The precise mechanism of action and potential therapeutic applications of 6,7-Dimethoxy-3,4-dihydro-2H-isoquinolin-1-one are areas of ongoing research.

InChI:InChI=1/C11H13NO3/c1-14-9-5-7-3-4-12-11(13)8(7)6-10(9)15-2/h5-6H,3-4H2,1-2H3,(H,12,13)

Upstream product

• 853925-01-6 1-allyl-8,9-dimethoxy-1,2,3,5,6,10b-hexahydro-pyrrolo[2,1-a]isoquinoline 
• 15547-61-2 5,6-dimethoxy-indan-1-one oxime 
• 132589-67-4 2-(2,2-Dimethyl-propionyl)-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 67-56-1 methanol 
• 412337-64-5 6,7-dimethoxy-1-(2-nitro-benzyl)-3,4-dihydro-isoquinoline 
• 499140-42-0 6,7-dimethoxy-1-(3-methoxy-2-nitro-benzyl)-3,4-dihydro-isoquinoline 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 41993-68-4 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid ethyl ester 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 3382-18-1 6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 56-23-5 tetrachloromethane 
• 17889-63-3 N-<2-(3,4-Dimethoxyphenyl)ethyl>carbamidsaeureethylester 
• 10025-87-3 trichlorophosphate 

Downstream Products

• 66510-55-2 2-(3-chloropropyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisochinolinone 
• 131637-22-4 6,7-Dimethoxy-2-prop-2-ynyl-3,4-dihydro-2H-isoquinolin-1-one 
• 6514-05-2 6,7-dimethoxy-N-methyl-2H-3,4-dihydroisoquinolin-1-one 
• 24456-59-5 6,7-dimethoxy-3,4-dihydroisoquinoline-1(2H)-thione 
• 32255-47-3 5,6-dihydro-2,3-dimethoxy-8H-dibenzo[a,g]quinolizin-8-one 
• 866756-40-3 2-(2-bromobenzoyl)-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 16101-63-6 6,7-dimethoxyisoquinoline-1(2H)-one 
• 103936-91-0 2-(3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-1(2H)-one 
• 76201-90-6 6,7-dimethoxy-1-<(para-chloro)phenyl>-3,4-dihydroisoquinoline 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 61011-86-7 5,6-dihydro-2,3-dimethoxy-8H-isoquinol<1,2-b>quinazolin-8-one 
• 116578-22-4 2-[N-Methyl-N-(4-(thien-2-yl)-butyl)-3-amino-propyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride 

Relevant articles and documents

Solid-phase synthesis of isoquinolinones using Bischler-Napieralski cyclization

A traceless solid-phase synthetic approach to isoquinolinones is described here. This approach allows introducing both electron-donating as well as electron-withdrawing moieties on the benzene nuclei of isoquinolinones with high yields and purities. Isoquinolinone is a structural unit found in many natural products having various important biological activities. A traceless solid-phase synthetic approach has been developed to prepare isoquinolinone derivatives. This approach enables one to synthesize isoquinolinones having various moieties on benzene nuclei and also can produce derivatives with a proton on the amide nitrogen.

Easy Access to 2,4-Disubstituted Cyclopentenones by a Gold(III)-Catalyzed A3-Coupling/Cyclization Cascade

An efficient and convenient synthesis of 2,4-disubstituted cyclopentenones has been achieved through a Au(III)-catalyzed isomerization-A3-coupling/cyclization cascade. A possible mechanism involving an initial Au(III)-catalyzed isomerization, A3-type coupling, and cyclization via an enol intermediate is postulated.

A g-C3N4-based heterogeneous photocatalyst for visible light mediated aerobic benzylic C-H oxygenations

A metal-free heterogeneous photocatalytic system has been developed for highly efficient benzylic C-H oxygenations using oxygen as an oxidant. This visible light mediated oxidation reaction utilizes graphitic carbon nitride (g-C3N4) as a recyclable, nontoxic and low cost photocatalyst. Mild reaction conditions allow for the generation of synthetically and biologically valued isochromannones, phthalides, isoquinolinones, isoindolinones and xanthones from readily accessible alkyl aromatic precursors in good yields. The heterogeneous nature of the g-C3N4 catalytic system enables easy recovery and recycling as well as the use in multiple runs without loss of activity. The synthetic utility of this "green" methodology was further demonstrated by applying in bioactive and drug valued target syntheses.