4(1H)-Quinolinone, 2-(4-methoxyphenyl)-1-methyl-

Base Information

• Chemical Name: 4(1H)-Quinolinone, 2-(4-methoxyphenyl)-1-methyl-
• CAS No.: 246181-55-5
• Molecular Formula: C17H15NO2
• Molecular Weight: 265.312
• DSSTox Substance ID: DTXSID90356563
• Nikkaji Number: J1.138.322J
• Wikidata: Q82135967
• ChEMBL ID: CHEMBL1509012
• Mol file: 246181-55-5.mol

Synonyms:N-methyl-2-(p-methoxyphenyl)-quinolin-4(1H)-one;2-(4-methoxyphenyl)-1-methyl-4(1H)-quinolinone;HMS2332I11;2-(4-methoxyphenyl)-1-methyl-4-quinolone;2-(4-methoxyphenyl)-1-methylquinolin-4(1H)-one;

Chemical Property of 4(1H)-Quinolinone, 2-(4-methoxyphenyl)-1-methyl-

Chemical Property:

• PSA: 31.23000
• LogP: 3.21410
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 265.110278721
• Heavy Atom Count: 20
• Complexity: 396

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=CC=CC=C2C(=O)C=C1C3=CC=C(C=C3)OC

Technology Process of 4(1H)-Quinolinone, 2-(4-methoxyphenyl)-1-methyl-

There total 26 articles about 4(1H)-Quinolinone, 2-(4-methoxyphenyl)-1-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C17H15NO2 → 1-methyl-2-(4’-methoxyphenyl)-1H-4-quinolone (246181-55-5)

Guidance literature:

With sodium methylate; In methanol; at 65 ℃; regioselective reaction;

DOI:10.1002/bkcs.12239

Reference yield: 81.0%

C17H16BrNO2 (1516898-18-2) → 1-methyl-2-(4’-methoxyphenyl)-1H-4-quinolone (246181-55-5)

Guidance literature:

With sodium hydride; In 1,2-dimethoxyethane;

DOI:10.5012/bkcs.2013.34.10.3117

Reference yield: 65.0%

N-(2-acetyl-phenyl)-4-methoxy-benzamide (33768-41-1) + methyl iodide (74-88-4) → 1-methyl-2-(4’-methoxyphenyl)-1H-4-quinolone (246181-55-5)

Guidance literature:

N-(2-acetyl-phenyl)-4-methoxy-benzamide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran;

DOI:10.1016/j.tet.2015.07.058

upstream raw materials:

2-(4-methoxyphenyl)quinoline

methyl trifluoromethanesulfonate

N-(2-acetyl-phenyl)-4-methoxy-benzamide

methyl iodide

Downstream raw materials:

3-iodo-2-(4'-methoxyphenyl)-1-methylquinolin-4(1H)-one

2-(4-hydroxyphenyl)-1-methylquinolin-4(1H)-one