(3S,4S)-1-N-CBZ-3-(N-BOC-AMINO)-4-HYDROXYMETHYLPYRROLIDINE

Base Information

• Chemical Name: (3S,4S)-1-N-CBZ-3-(N-BOC-AMINO)-4-HYDROXYMETHYLPYRROLIDINE
• CAS No.: 246510-69-0
• Molecular Formula: C18H26N2O5
• Molecular Weight: 350.415
• Mol file: 246510-69-0.mol

Synonyms:(3S,4S)-3-tert-Butoxycarbonylamino-4-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester;(3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-hydroxymethylpyrrolidine;Benzyl (3S,4S)-3-[(tert-butoxycarbonyl)amino]-4-(hydroxymethyl)-1-pyrrolidinecarboxylate;(3S,4S)-1-N-CBZ-3-(N-BOC-AMINO)-4-HYDROXYMETHYLPYRROLIDINE;1-Pyrrolidinecarboxylic acid,3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-(hydroxymethyl)-,phenylmethyl ester,(3S,4S);benzyl (3S,4S)-3-tert-butoxycarbonylamino-4-hydroxymethyl-pyrrolidine-1-carboxylate;

Chemical Property of (3S,4S)-1-N-CBZ-3-(N-BOC-AMINO)-4-HYDROXYMETHYLPYRROLIDINE

Chemical Property:

• PSA: 88.10000
• LogP: 2.46940

Purity/Quality:

97% ^*data from raw suppliers

(3S,4S)-3-TERT-BUTOXYCARBONYLAMINO-4-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3S,4S)-1-N-CBZ-3-(N-BOC-AMINO)-4-HYDROXYMETHYLPYRROLIDINE

There total 15 articles about (3S,4S)-1-N-CBZ-3-(N-BOC-AMINO)-4-HYDROXYMETHYLPYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzyl (cis)-2,2-dimethylhexahydropyrrolo[3,4-d][1,3]oxazine-6(4H)-carboxylate (R)-mandelate + di-tert-butyl dicarbonate (24424-99-5) → benzyl (3S,4S)-3-tert-butoxycarbonylamino-4-hydroxymethyl-pyrrolidine-1-carboxylate (246510-69-0,246510-67-8)

Guidance literature:

benzyl (cis)-2,2-dimethylhexahydropyrrolo[3,4-d][1,3]oxazine-6(4H)-carboxylate (R)-mandelate; With sulfuric acid; In ethanol; water; at 20 ℃; for 16h;

di-tert-butyl dicarbonate; With sodium hydroxide; In ethanol; water; at 10 - 20 ℃; for 4h; pH=10;

Reference yield: 98.0%

→ benzyl (3S,4S)-3-tert-butoxycarbonylamino-4-hydroxymethyl-pyrrolidine-1-carboxylate (246510-69-0,246510-67-8)

Guidance literature:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → benzyl (3S,4S)-3-tert-butoxycarbonylamino-4-hydroxymethyl-pyrrolidine-1-carboxylate (246510-69-0,246510-67-8)

Guidance literature:

Benzyl (4aS,7aS)-2,2-dimethylhexahydropyrrolo[3,4-d][1,3]oxazine-6(4H)-carboxylate (R)-mandelate; With sulfuric acid; In ethanol; water; at 20 ℃; for 16h;

di-tert-butyl dicarbonate; In ethanol; water; at 10 - 20 ℃; for 4h; pH=~ 10;

upstream raw materials:

di-tert-butyl dicarbonate

benzyl (cis)-3-amino-4-(hydroxymethyl)-1-pyrrolidinecarboxylate

Benzyl (4aS,7aS)-2,2-dimethylhexahydropyrrolo[3,4-d][1,3]oxazine-6(4H)-carboxylate (R)-mandelate

benzyl (cis)-3-amino-4-(hydroxymethyl)-1-pyrrolidinecarboxylate (S)-mandelate

Downstream raw materials:

benzyl (3S,4S)-3-tert-butoxycarbonylamino-4-methylsulfonyloxymethyl-pyrrolidine-1-carboxylate

(3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-(p-toluenesulfonyloxy)methylpyrrolidine

(3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-(phenylsulfanil)methylpyrrolidine

(3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-formylpyrrolidine