(3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-(phenylsulfanil)methylpyrrolidine

Base Information

• Chemical Name: (3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-(phenylsulfanil)methylpyrrolidine
• CAS No.: 869956-21-8
• Molecular Formula: C₂₄H₃₀N₂O₄S
• Molecular Weight: 442.579
• Mol file: 869956-21-8.mol

Synonyms:(3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-(phenylsulfanil)methylpyrrolidine

Chemical Property of (3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-(phenylsulfanil)methylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-(phenylsulfanil)methylpyrrolidine

There total 1 articles about (3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-(phenylsulfanil)methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.6%

benzyl (3S,4S)-3-tert-butoxycarbonylamino-4-hydroxymethyl-pyrrolidine-1-carboxylate (246510-69-0,246510-67-8) + diphenyldisulfane (882-33-7) → (3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-(phenylsulfanil)methylpyrrolidine (869956-21-8)

Guidance literature:

benzyl (3S,4S)-3-tert-butoxycarbonylamino-4-hydroxymethyl-pyrrolidine-1-carboxylate; diphenyldisulfane; With tributylphosphine; In tetrahydrofuran; for 1h; Heating / reflux;

With sodium hydroxide; In tetrahydrofuran; water;

Reference yield: 72.1%

(3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-(phenylsulfanil)methylpyrrolidine (869956-21-8) → (3S,4S)-3-(tert-Butoxycarbonyl)amino-4-methylpyrrolidine (127199-54-6,1334481-84-3)

Guidance literature:

(3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-(phenylsulfanil)methylpyrrolidine; With hydrogen; In ethanol; at 50 ℃; for 18h;

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 3h;

upstream raw materials:

benzyl (3S,4S)-3-tert-butoxycarbonylamino-4-hydroxymethyl-pyrrolidine-1-carboxylate

diphenyldisulfane

Downstream raw materials:

(3S,4S)-3-(tert-Butoxycarbonyl)amino-4-methylpyrrolidine