3-(3-(Benzyloxy)-4-methoxyphenyl)acrylic acid

Base Information

• Chemical Name: 3-(3-(Benzyloxy)-4-methoxyphenyl)acrylic acid
• CAS No.: 24807-37-2
• Molecular Formula: C17H16O4
• Molecular Weight: 284.312
• European Community (EC) Number: 651-800-7
• Nikkaji Number: J1.086.998F
• Mol file: 24807-37-2.mol

Synonyms:3-(3-(Benzyloxy)-4-methoxyphenyl)acrylic acid;24807-37-2;SCHEMBL1609268;(E)-3-(4-methoxy-3-phenylmethoxyphenyl)prop-2-enoic acid;3-Benzyloxy-4-methoxycinnamic acid;STL510491;AKOS004907216;BS-50608;F71674;(2E)-3-[3-(BENZYLOXY)-4-METHOXYPHENYL]PROP-2-ENOIC ACID

Chemical Property of 3-(3-(Benzyloxy)-4-methoxyphenyl)acrylic acid

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 284.10485899
• Heavy Atom Count: 21
• Complexity: 347

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C=CC(=O)O)OCC2=CC=CC=C2
• Isomeric SMILES: COC1=C(C=C(C=C1)/C=C/C(=O)O)OCC2=CC=CC=C2

Technology Process of 3-(3-(Benzyloxy)-4-methoxyphenyl)acrylic acid

There total 11 articles about 3-(3-(Benzyloxy)-4-methoxyphenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-ethyl 3-(3-benzyl-oxy-4-methoxyphenyl)acrylate (71146-88-8) → (E)-3-(3-(benzyloxy)-4-methoxyphenyl)acrylic acid (24807-37-2)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 48h;

DOI:10.1016/j.ejmech.2018.10.025

Reference yield: 96.0%

malonic acid (141-82-2) + 3-benzyloxy-4-methoxybenzaldehyde (6346-05-0) → (E)-3-(3-(benzyloxy)-4-methoxyphenyl)acrylic acid (24807-37-2)

Guidance literature:

With piperidine; pyridine; for 0.0833333h; microwave irradiation;

DOI:10.1080/00397919908085805

Reference yield:

trans-3-hydroxy-4-methoxycinnamic acid (537-73-5) + benzyl bromide (100-39-0) → (E)-3-(3-(benzyloxy)-4-methoxyphenyl)acrylic acid (24807-37-2)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃;

DOI:10.1016/j.ejmech.2017.11.066

upstream raw materials:

malonic acid

3-benzyloxy-4-methoxybenzaldehyde

3-Benzylisoferulic acid methyl ester

isovanillin

Downstream raw materials:

C₁₇H₁₅ClO₃