2-chloro-4,5-dimethoxybenzonitrile

Base Information

• Chemical Name: 2-chloro-4,5-dimethoxybenzonitrile
• CAS No.: 248595-18-8
• Molecular Formula: C₉H₈ClNO₂
• Molecular Weight: 197.621
• Mol file: 248595-18-8.mol

Synonyms:

Chemical Property of 2-chloro-4,5-dimethoxybenzonitrile

Chemical Property:

Purity/Quality:

99%,98% ^*data from raw suppliers

2-chloro-4,5-dimethoxybenzonitrile 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-4,5-dimethoxybenzonitrile

There total 3 articles about 2-chloro-4,5-dimethoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

C10H12ClNO3 (1428637-07-3) → 2-chloro-3,4-dimethoxybenzonitrile (248595-18-8)

Guidance literature:

With [Ru(η⁶-p-cymene)Cl₂]₂; acrylic acid methyl ester; diphenyl acetylene; In isopropyl alcohol; at 100 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1039/c3cc41124a

Reference yield: 80.0%

C10H12ClNO3 (1428637-07-3) + C9H8BrNO3 (1428637-20-0) → 6-bromobenzo[d][1,3]dioxole-5-carbonitrile (6120-26-9) + 2-chloro-3,4-dimethoxybenzonitrile (248595-18-8)

Guidance literature:

With [Ru(η⁶-p-cymene)Cl₂]₂; diphenyl acetylene; In isopropyl alcohol; at 100 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1039/c3cc41124a

Reference yield: 59.0%

3-(2-chloro-4,5-dimethoxy-phenyl)-6,6a-dihydro-3aH-furo[3,4-d]isoxazol-4-one → 2-chloro-3,4-dimethoxybenzonitrile (248595-18-8)

Guidance literature:

With potassium permanganate; sodium acetate; In 1,4-dioxane; for 24h; Heating;

DOI:10.1515/HC.2001.7.3.209

upstream raw materials:

C₁₀H₁₂ClNO₃

C₉H₈BrNO₃