N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester

Base Information

Chemical Name:N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester
CAS No.:249736-45-6
Molecular Formula:C12H22N2O4
Molecular Weight:258.318
Hs Code.:
Mol file:249736-45-6.mol

Synonyms:[(S)-1-Hydroxymethyl-2-((S)-2-oxo-pyrrolidin-3-yl)-ethyl]-carbamic acid tert-butyl ester;[2-hydroxy-1-(2-oxo-pyrrolidin-3-ylmethyl)-ethyl]-carbamic acid tert-butyl ester;tert-butyl (1S)-2-hydroxy-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}ethylcarbamate;tert-butyl (2S)-3-[(3'S)-2'-oxo-3'-pyrrolidinyl]-1-propanol-2-ylcarbamate;N-[(1S)-1-(Hydroxymethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbamic Acid tert-Butyl Ester;

Suppliers and Price of N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[(1S)-1-(Hydroxymethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbamicAcidtert-ButylEster
25mg
$ 175.00

Medical Isotopes, Inc.
N-[(1S)-1-(Hydroxymethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbamicAcidtert-ButylEster
25 mg
$ 640.00

AK Scientific
Tert-butylN-[(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamate
1g
$ 1545.00

Total 3 raw suppliers

Chemical Property of N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester

Chemical Property:

Melting Point:>125°C (dec.)
Boiling Point:480.0±20.0 °C(Predicted)
PKA:11.87±0.46(Predicted)
PSA：87.66000
Density:1.132±0.06 g/cm3(Predicted)
LogP:1.11790
Storage Temp.:Refrigerator, under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

N-[(1S)-1-(Hydroxymethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbamicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester is used in the preparation of Rhinovirus protease inhibitors.

Technology Process of N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester

There total 13 articles about N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 328086-60-8
(2S)-2-(tert-butoxycarbonylamino)-3-[(3'S)-2'-oxo-3'-pyrrolidinyl]propanoic acid methy ester

: 249736-45-6
[2-hydroxy-1S-(2-oxopyrrolidin-3S-ylmethyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: With lithium tetrahydridoborate; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield: 69.0%

: [2-hydroxy-1S-(2-oxopyrrolidin-3-ylidenemethyl)ethyl]carbamic acid tert-butyl ester

: 249736-45-6
[2-hydroxy-1S-(2-oxopyrrolidin-3S-ylmethyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; (S)-BINAP-RuCl; In methanol; at 20 ℃; for 72h; under 62059.4 Torr;
DOI:10.1021/jm010435c

Reference yield:

: 59279-60-6,130622-05-8,861658-15-3
dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate

: 249736-45-6
[2-hydroxy-1S-(2-oxopyrrolidin-3S-ylmethyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiN(SiMe₃)2 / tetrahydrofuran / 3 h / -78 °C

1.2: 82 percent / tetrahydrofuran / 3.5 h

2.1: H₂ / PtO₂ / methanol; CHCl₃ / 12 h / 25 °C

3.1: NaOAc / methanol; CHCl₃ / 12 h / Heating

4.1: 89 percent / NaBH₄; LiCl / ethanol; tetrahydrofuran / 18 h / 25 °C

With sodium tetrahydridoborate; hydrogen; anhydrous Sodium acetate; lithium chloride; lithium hexamethyldisilazane; Adams’s catalyst; In tetrahydrofuran; methanol; ethanol; chloroform;
DOI:10.1016/j.bmc.2005.05.065