1,2-Hydrazinedicarboxylic acid, 1-[(1S)-1-(1,3-benzodioxol-5-yl)-2-[[(1S,2S)-2-hydroxy-1-methyl-2-phen ylethyl]methylamino]-2-oxoethyl]-, bis(1,1-dimethylethyl) ester

Base Information

• Chemical Name: 1,2-Hydrazinedicarboxylic acid, 1-[(1S)-1-(1,3-benzodioxol-5-yl)-2-[[(1S,2S)-2-hydroxy-1-methyl-2-phen ylethyl]methylamino]-2-oxoethyl]-, bis(1,1-dimethylethyl) ester
• CAS No.: 250665-93-1
• Molecular Formula: C29H39N3O8
• Molecular Weight: 557.644
• Mol file: 250665-93-1.mol

Synonyms:

Chemical Property of 1,2-Hydrazinedicarboxylic acid, 1-[(1S)-1-(1,3-benzodioxol-5-yl)-2-[[(1S,2S)-2-hydroxy-1-methyl-2-phen ylethyl]methylamino]-2-oxoethyl]-, bis(1,1-dimethylethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-Hydrazinedicarboxylic acid, 1-[(1S)-1-(1,3-benzodioxol-5-yl)-2-[[(1S,2S)-2-hydroxy-1-methyl-2-phen ylethyl]methylamino]-2-oxoethyl]-, bis(1,1-dimethylethyl) ester

There total 3 articles about 1,2-Hydrazinedicarboxylic acid, 1-[(1S)-1-(1,3-benzodioxol-5-yl)-2-[[(1S,2S)-2-hydroxy-1-methyl-2-phen ylethyl]methylamino]-2-oxoethyl]-, bis(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(Z)-N-[(tert-butoxy)carbonyl]imino(tert-butoxy)formamide (870-50-8) + (+)-<1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide (247118-52-1) → [2S,1'S,2'S]-(+)-2-[N,N'-bis(1,1-dimethylethoxycarbonyl)hydrazino]-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide (250665-93-1)

Guidance literature:

(+)-<1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

(Z)-N-[(tert-butoxy)carbonyl]imino(tert-butoxy)formamide; In tetrahydrofuran; at -105 ℃;

DOI:10.1016/S0040-4039(99)01475-6

Reference yield: 91.0%

1,2-bis(t-butyloxycarbonyl)hydrazine (16466-61-8) + (+)-<1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide (247118-52-1) → [2S,1'S,2'S]-(+)-2-[N,N'-bis(1,1-dimethylethoxycarbonyl)hydrazino]-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide (250665-93-1)

Guidance literature:

(+)-<1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.33333h;

1,2-bis(t-butyloxycarbonyl)hydrazine; In tetrahydrofuran; hexane; at -105 ℃; for 1h;

DOI:10.1002/1099-0690(200111)2001:22<4343::AID-EJOC4343>3.0.CO;2-D

Reference yield: 91.0%

di-tert-butyl-diazodicarboxylate (870-50-8) + (+)-<1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide (247118-52-1) → [2S,1'S,2'S]-(+)-2-[N,N'-bis(1,1-dimethylethoxycarbonyl)hydrazino]-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide (250665-93-1) + C29H39N3O8

Guidance literature:

(+)-<1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

di-tert-butyl-diazodicarboxylate; In tetrahydrofuran; at -105 ℃;

DOI:10.1016/S0957-4166(02)00181-7

upstream raw materials:

(Z)-N-[(tert-butoxy)carbonyl]imino(tert-butoxy)formamide

(+)-<1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide

1,2-bis(t-butyloxycarbonyl)hydrazine

di-tert-butyl-diazodicarboxylate

Downstream raw materials:

(2S)-(-)-2-(2,3-dimethoxybenzyl)-N-methylamino-2-(3,4-methylenedioxyphenyl)ethanol

(2S)-(+)-2-(2,3-dimethoxybenzyl)amino-2-(3,4-methylenedioxyphenyl)ethanol

(2S)-(+)-(E)-2-(2,3-dimethoxybenzylideneamino)-2-(3,4-methylenedioxyphenyl)ethanol

(S)-Benzo[1,3]dioxol-5-yl-[(2,3-dimethoxy-benzyl)-methyl-amino]-acetaldehyde