(2S)-(+)-(E)-2-(2,3-dimethoxybenzylideneamino)-2-(3,4-methylenedioxyphenyl)ethanol

Base Information

Chemical Name:(2S)-(+)-(E)-2-(2,3-dimethoxybenzylideneamino)-2-(3,4-methylenedioxyphenyl)ethanol
CAS No.:394740-07-9
Molecular Formula:C₁₈H₁₉NO₅
Molecular Weight:329.353
Hs Code.:

Synonyms:(2S)-(+)-(E)-2-(2,3-dimethoxybenzylideneamino)-2-(3,4-methylenedioxyphenyl)ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-(+)-(E)-2-(2,3-dimethoxybenzylideneamino)-2-(3,4-methylenedioxyphenyl)ethanol

Chemical Property:

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Technology Process of (2S)-(+)-(E)-2-(2,3-dimethoxybenzylideneamino)-2-(3,4-methylenedioxyphenyl)ethanol

There total 5 articles about (2S)-(+)-(E)-2-(2,3-dimethoxybenzylideneamino)-2-(3,4-methylenedioxyphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 394740-06-8,179811-73-5
(2S)-(-)-2-amino-2-(3,4-methylenedioxyphenyl)ethanol

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 394740-07-9
(2S)-(+)-(E)-2-(2,3-dimethoxybenzylideneamino)-2-(3,4-methylenedioxyphenyl)ethanol

Guidance literature:: With molecular sieve; 4 A molecular sieve; In benzene; for 4h; Heating;
DOI:10.1002/1099-0690(200111)2001:22<4343::AID-EJOC4343>3.0.CO;2-D

Reference yield:

: 250666-02-5
(S)-(+)-3,4-(methylenedioxy)phenylglycine

: 394740-07-9
(2S)-(+)-(E)-2-(2,3-dimethoxybenzylideneamino)-2-(3,4-methylenedioxyphenyl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / LiBH₄; TMSCl / tetrahydrofuran / 25 h / 0 - 20 °C

2: 85 percent / molecular sieves, 4 Angstroem / benzene / 4 h / Heating

With lithium borohydride; chloro-trimethyl-silane; molecular sieve; 4 A molecular sieve; In tetrahydrofuran; benzene;
DOI:10.1002/1099-0690(200111)2001:22<4343::AID-EJOC4343>3.0.CO;2-D

Reference yield:

: 247118-52-1
(+)-<1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4-methylenedioxyphenyl)acetamide

: 394740-07-9
(2S)-(+)-(E)-2-(2,3-dimethoxybenzylideneamino)-2-(3,4-methylenedioxyphenyl)ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: nBuLi; iPr₂NH / tetrahydrofuran; hexane / 1.33 h / -78 - 20 °C

1.2: 91 percent / tetrahydrofuran; hexane / 1 h / -105 °C

2.1: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

2.2: 79 percent / H₂ / Ni/Raney / CH₂Cl₂ / 48 h / 7757.22 Torr

3.1: 89 percent / H₂SO₄; H₂O / dioxane / 6 h / Heating

4.1: 78 percent / LiBH₄; TMSCl / tetrahydrofuran / 25 h / 0 - 20 °C

5.1: 85 percent / molecular sieves, 4 Angstroem / benzene / 4 h / Heating

With lithium borohydride; n-butyllithium; chloro-trimethyl-silane; molecular sieve; 4 A molecular sieve; sulfuric acid; water; diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; benzene;
DOI:10.1002/1099-0690(200111)2001:22<4343::AID-EJOC4343>3.0.CO;2-D