2-Hydroxymethyl Olanzapine

Base Information

Chemical Name:2-Hydroxymethyl Olanzapine
CAS No.:174756-45-7
Molecular Formula:C₁₇H₂₀N₄OS
Molecular Weight:328.438
Hs Code.:
Mol file:174756-45-7.mol

Synonyms:LY 290411

Suppliers and Price of 2-Hydroxymethyl Olanzapine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-HydroxymethylOlanzapine
25mg
$ 3025.00

TRC
2-HydroxymethylOlanzapine
1mg
$ 185.00

Medical Isotopes, Inc.
2-HydroxymethylOlanzapine-d3(Major)
1 mg
$ 725.00

American Custom Chemicals Corporation
2-HYDROXY METHYL OLANZAPINE 95.00%
10MG
$ 1963.50

Total 13 raw suppliers

Chemical Property of 2-Hydroxymethyl Olanzapine

Chemical Property:

Vapor Pressure:4.3E-12mmHg at 25°C
Melting Point:210-212?C
Boiling Point:530.7°C at 760 mmHg
Flash Point:274.8°C
PSA：79.34000
Density:1.4g/cm³
LogP:2.07250
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

2-HydroxymethylOlanzapine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A minor metabolite of Olanzapine. A minor metabolite of Olanzapine A minor labelled metabolite of Olanzapine

Technology Process of 2-Hydroxymethyl Olanzapine

There total 7 articles about 2-Hydroxymethyl Olanzapine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4651-82-5
2-amino-3-cyanothiophene

: 174756-45-7
2-hydroxymethyl olanzapine

Guidance literature:: Multi-step reaction with 5 steps

1: LiOH / dimethylsulfoxide

2: POCl₃

3: SnCl₂, aq. HCl / ethanol

4: NaBH₄ / ethanol

5: toluene; dimethylsulfoxide / Heating

With hydrogenchloride; lithium hydroxide; sodium tetrahydroborate; tin(ll) chloride; trichlorophosphate; In ethanol; dimethyl sulfoxide; toluene;
DOI:10.1016/S0960-894X(96)00567-7

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 174756-45-7
2-hydroxymethyl olanzapine

Guidance literature:: Multi-step reaction with 5 steps

1: LiOH / dimethylsulfoxide

2: POCl₃

3: SnCl₂, aq. HCl / ethanol

4: NaBH₄ / ethanol

5: toluene; dimethylsulfoxide / Heating

With hydrogenchloride; lithium hydroxide; sodium tetrahydroborate; tin(ll) chloride; trichlorophosphate; In ethanol; dimethyl sulfoxide; toluene;
DOI:10.1016/S0960-894X(96)00567-7

Reference yield:

: 186792-85-8
2-[(2-nitrophenyl)amino]-thiophene-3-carbonitrile

: 174756-45-7
2-hydroxymethyl olanzapine

Guidance literature:: Multi-step reaction with 4 steps

1: POCl₃

2: SnCl₂, aq. HCl / ethanol

3: NaBH₄ / ethanol

4: toluene; dimethylsulfoxide / Heating

With hydrogenchloride; sodium tetrahydroborate; tin(ll) chloride; trichlorophosphate; In ethanol; dimethyl sulfoxide; toluene;
DOI:10.1016/S0960-894X(96)00567-7