4651-82-5

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C5H4N2S/c6-3-4-1-2-8-5(4)7/h1-2H,7H2

Upstream product

• 40018-26-6 1,4-dithiane-2,5-diol 
• 109-77-3 malononitrile 
• 75-07-0 acetaldehyde 

Downstream Products

• 14080-50-3 thieno[2,3-d]pyrimidin-4(3H)one 
• 14080-56-9 thieno[2,3-d]pyrimidin-4-amine 
• 63647-03-0 (pyrrolyl-1)-2 thiophene carbonitrile-3 
• 18740-44-8 thieno<2,3-d>pyrimidin-2,4(1H,3H)-dithione 
• 130750-44-6 2-amino-5-<<3-trifluoromethyl)phenyl>thio>thiophen-3-carbonitril 
• 130750-45-7 2-amino-4,5-bis<<3-(trifluoromethyl)phenyl>thio>thiophen-3-carbonitril 
• 130750-42-4 2,4-diaminothieno<2,3-d>pyrimidin 
• 139308-44-4 N-phenyl-N'-(2-cyanothieno)carbodiimide 
• 139308-40-0 2-<(triphenylphosphoranylidene)amino>-3-cyanothiophene 
• 75860-78-5 4-aminothieno<2,3-d>pyrimidin-2-one 
• 43028-71-3 2-formylaminothiophene-3-carboxamide 
• 14080-59-2 4-chlorothieno[2,3-d]pyrimidine 
• 186792-87-0 5-Formyl-2-(2-nitro-phenylamino)-thiophene-3-carbonitrile 
• 186792-89-2 4-Cyano-5-(2-nitro-phenylamino)-thiophene-2-carboxylic acid 

Relevant academic research and scientific papers

Design, synthesis and antifungal activity of new schiff bases bearing 2-aminothiophene derivatives obtained by molecular simplification

Seventeen Schiff bases bearing 2-aminothiophene derivatives were designed and synthesized using molecular simplification. The resulting compounds (4a-4q) were evaluated for their in vitro antifungal activity against dermatophytes. Prediction of their drug

6-Cinnamoyl-4-arylaminothienopyrimidines as highly potent cytotoxic agents: Design, synthesis and structure-activity relationship studies

In this paper, we described the synthesis and cytotoxic activities of two new series of thieno[2,3-d]pyrimidine and thieno[3,2-d] pyrimidine derivatives. Most of the synthesized compounds had significant antiproliferative activities against PC3, MDA-MB-23

HPK1 inhibitor and application thereof

The invention belongs to the technical field of medicines, and specifically relates to an HPK1 inhibitor compound as shown in a formula (I) which is described in the specification or a pharmaceutically-acceptable salt and a stereoisomer of the HPK1 inhibi

Facile pathway for synthesis of two efficient catalysts for preparation of 2-aminothiophenes and tetrahydrobenzo[b]pyrans

Abstract: We report here a new magnetically recyclable catalyst consisting of iron-substituted Keggin-type heteropolyacid (HPA) grafted on modified Fe3O4 nanoparticles. The synthesized hybrid nanomaterial exhibited the excellent catalytic efficiency in condensation reaction for the preparation of tetrahydrobenzo[b]pyrans under solvent-free conditions as well as in the synthesis of 2-aminothiophenes via Gewald reaction. It must be noted that, HPA supported magnetite nanoparticles catalyzed the preparation of tetrahydrobenzo[b]pyrans, whereas for Gewald reaction amine-functionalized magnetite nanoparticles acted as a catalyst. Different characterization techniques such as Fourier transform infrared (FT-IR), X-ray powder diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM) were used to characterize the hybrid nanomaterial. The reusability of catalyst was affirmed by using in consecutive runs for five times. Performance of prepared catalyst was compared with the various previously reported catalysts; the newly synthesized catalysts found to be most efficient with regard to reaction time, yield and ease of catalyst separation. Graphical Abstract: [Figure not available: see fulltext.].

Ethylene diamine grafted nanoporous UiO-66 as an efficient basic catalyst in the multi-component synthesis of 2-aminithiophenes

This study demonstrates ED-UiO-66 as a novel and effective solid nanoporous basic catalyst prepared through the amine grafting onto the pores of UiO-66. The manufactured nanoparticles were identified by FT-IR, XRD, TGA, FESEM, TEM, CHN and BET and the characterization results certified formation of a single phase nanoporous substance with the medium grain size less than 90?nm. The synthesized material was employed as an efficient catalyst for the preparation of 2-aminotiophenes through the Gewald method. This thermochemically stable nanocatalyst was environmentally safe, reusable and economic. Therefore, this methodology can be simply extended for industrial goals.

A green chemical approach: a straightforward one-pot synthesis of 2-aminothiophene derivatives via Gewald reaction in deep eutectic solvents

Abstract: The synergic effect of choline chloride/urea as a deep eutectic solvent was investigated in the synthesis of 2-aminothiophene derivatives via a three-component cyclocondensation of a ketone or an aldehyde with activated nitriles and elemental sulfur catalyzed by NaOH as cheap and highly accessible base. The advantages of this catalytic protocol are eco-friendly, easy to set up, reusability, and a simple separation and purification of products without using chromatography in high yields at short times. Graphical abstract: [Figure not available: see fulltext.]

TiO2/nanoclinoptilolite as an efficient nanocatalyst in the synthesis of substituted 2-aminothiophenes

TiO2/nanoclinoptilolite (TiO2/NCP) was prepared by the mediation of hexadecyltrimethylammonium (HDTMA) as surfactant and used as an effective heterogeneous nanocatalyst for the preparation of substituted 2-aminotiophenes. The modified HDTMA/NCP was impregnated with titanium(IV) chloride solution followed by calcination at 500?°C for 20?h. The obtained nanocomposite was characterized using Fourier transform infrared spectroscopy, field emission scanning electron microscopy, inductively coupled plasma optical emission spectroscopy and X-ray diffraction. Moreover, the prepared nanocomposite had high stability and recoverability under mild and solvent-free conditions.

Optical properties of thiophene-containing liquid crystalline and hybrid liquid crystalline materials

We report new mesogens made of thiophene and stilbene moieties as main building blocks that exhibit nematic and/or smectic phases. The liquid crystalline properties of their thiophene/azobenzene analogues have been found to be strongly suppressed compared to their thiophene/stilbene analogues. In twinned "bent-core" thiophene/azobenzene compound relatively strong fluorescence was found. A new hybrid material built of AuNPs coated with a thiophene-containing mesogenic ligand that forms a smectic phase is shown. In solutions of thiophene-mesogen coated AuNPs an unusual decrease of the ligand fluorescence decay rate was observed. Fluorescence lifetime increase is ascribed to two-point anchoring of ligand molecules resulting in molecule orientation tangential to the AuNP surface. UV-Visible absorption and fluorescence data of all synthesised compounds are presented. the Partner Organisations 2014.

An efficient synthesis of 2-aminothiophenes via the gewald reaction catalyzed by an N-methylpiperazine-functionalized polyacrylonitrile fiber

A new N-methylpiperazine-functionalized polyacrylonitrile fiber has been developed to catalyze the Gewald reaction between 2,5-dihydroxy-1,4-dithiane and activated nitriles to afford 3-substituted 2-aminothiophenes in good to excellent yields (65-91%). Low catalyst loading (8.0 mol%), simple procedure, high yields, excellent recyclability, and reusability (up to 10 times with minimal loss of catalytic activity) are attractive features of this fiber catalyst. Georg Thieme Verlag Stuttgart · New York.

NOVEL ANTI-CANCER COMPOUNDS

The present invention relates to compounds having cytostatic activity against tumor cells. The compounds of the invention are of formula (I), or derivatives hereof, wherein R0, R1, R2, A, and X have defined meanings as described in claim 1.