4651-82-5Relevant articles and documents
Design, synthesis and antifungal activity of new schiff bases bearing 2-aminothiophene derivatives obtained by molecular simplification
Luna, Isadora S.,Neves, Wendell W.,De Lima-Neto, Reginaldo G.,Albuquerque, Amanda P. B.,Pitta, Maíra G. R.,Rêgo, Moacyr J. B. M.,Neves, Rejane P.,Scotti, Marcus T.,Mendon?a, Francisco J. B.
, p. 1017 - 1029 (2021/05/19)
Seventeen Schiff bases bearing 2-aminothiophene derivatives were designed and synthesized using molecular simplification. The resulting compounds (4a-4q) were evaluated for their in vitro antifungal activity against dermatophytes. Prediction of their drug
HPK1 inhibitor and application thereof
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Paragraph 0272-0274, (2019/05/16)
The invention belongs to the technical field of medicines, and specifically relates to an HPK1 inhibitor compound as shown in a formula (I) which is described in the specification or a pharmaceutically-acceptable salt and a stereoisomer of the HPK1 inhibi
Ethylene diamine grafted nanoporous UiO-66 as an efficient basic catalyst in the multi-component synthesis of 2-aminithiophenes
Erfaninia,Tayebee,Dusek,Amini
, (2018/03/29)
This study demonstrates ED-UiO-66 as a novel and effective solid nanoporous basic catalyst prepared through the amine grafting onto the pores of UiO-66. The manufactured nanoparticles were identified by FT-IR, XRD, TGA, FESEM, TEM, CHN and BET and the characterization results certified formation of a single phase nanoporous substance with the medium grain size less than 90?nm. The synthesized material was employed as an efficient catalyst for the preparation of 2-aminotiophenes through the Gewald method. This thermochemically stable nanocatalyst was environmentally safe, reusable and economic. Therefore, this methodology can be simply extended for industrial goals.