2-AMINO-4,6-DICHLOROBENZOIC ACID

Base Information

• Chemical Name: 2-AMINO-4,6-DICHLOROBENZOIC ACID
• CAS No.: 20776-63-0
• Molecular Formula: C7H5 Cl2 N O2
• Molecular Weight: 206.028
• Hs Code.: 2922499990
• Mol file: 20776-63-0.mol

Synonyms:Anthranilicacid, 4,6-dichloro- (8CI); 2-Amino-4,6-dichlorobenzoic acid;4,6-Dichloroanthranilic acid; 6-Amino-2,4-dichlorobenzoic acid; NSC 154083

Chemical Property of 2-AMINO-4,6-DICHLOROBENZOIC ACID

Chemical Property:

• Vapor Pressure: 2.7E-06mmHg at 25°C
• Melting Point: 178.0-178.5 °C (decomp)
• Boiling Point: 375.2°Cat760mmHg
• PKA: 3.42±0.25(Predicted)
• Flash Point: 180.7°C
• PSA: 63.32000
• Density: 1.607g/cm³
• LogP: 2.85500
• Storage Temp.: Store below +30°C.
• Solubility.: 1.25g/l

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-4,6-dichlorobenzoic acid ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-4,6-DICHLOROBENZOIC ACID

There total 2 articles about 2-AMINO-4,6-DICHLOROBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4,6-dichloro-1H-indole-2,3-dione (18711-15-4) → 2-amino-4,6-dichlorobenzoic acid (20776-63-0)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In water; for 2h;

Reference yield:

→ 2-amino-4,6-dichlorobenzoic acid (20776-63-0)

Guidance literature:

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-amino-4,6-dichlorobenzoic acid (20776-63-0) → 4,6-dichloro-2-aminobenzoic acid methyl ester (147494-04-0)

Guidance literature:

diazomethane; 2-amino-4,6-dichlorobenzoic acid; In diethyl ether; at 20 ℃;

With acetic acid; In diethyl ether;

upstream raw materials:

4,6-dichloro-1H-indole-2,3-dione

Downstream raw materials:

2-(carboxymethyl-amino)-4,6-dichloro-benzoic acid

4,6-dichloro-2-aminobenzoic acid methyl ester

2-amino-4,6-dichloro-benzamide

2,4-dichloro-6-[(4-methyl-2-morpholin-4-yl-thiazole-5-carbonyl)-amino]-benzoic acid

Refernces

• 1、 -. "NOVEL SUBSTITUTED-1H-QUINAZOLINE-2,4-DIONE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME". Page/Page column 25-26. . Retrieved 2008/06/13.
• 2、 -. "3-aryl--3-methyl-quinoline-2, 4-diones, preparation method thereof, and pharmaceutical composition containing the same". Page/Page column 7. . Retrieved 2008/06/13.