Thiophen-3-amine hydrochloride

Base Information

• Chemical Name: Thiophen-3-amine hydrochloride
• CAS No.: 25475-76-7
• Molecular Formula: C4H5NS.ClH
• Molecular Weight: 135.61500
• Hs Code.: 2934999090
• European Community (EC) Number: 818-560-7
• DSSTox Substance ID: DTXSID30497106
• Mol file: 25475-76-7.mol

Synonyms:THIOPHEN-3-AMINE HYDROCHLORIDE;25475-76-7;thiophen-3-amine;hydrochloride;3-aminothiophene hydrochloride;thiophen-3-amine HCl;MFCD11226843;3-Thiophenamine, hydrochloride;SCHEMBL1031787;Thiophen-3-ylamine hydrochloride;DTXSID30497106;BEBOUWGYKDEYIL-UHFFFAOYSA-N;AMY15435;CS-D0258;THIOPHEN-3-AMINEHYDROCHLORIDE;AKOS016007128;MB09694;AS-60076;SY317146;FT-0737752;Thiophen-3-amine--hydrogen chloride (1/1);EN300-80184;D77326;A877575;Z1962138158

Chemical Property of Thiophen-3-amine hydrochloride

Chemical Property:

• PSA: 54.26000
• LogP: 2.71350
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 134.9909481
• Heavy Atom Count: 7
• Complexity: 46.8

Purity/Quality:

98%min ^*data from raw suppliers

Thiophen-3-aminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC=C1N.Cl

Technology Process of Thiophen-3-amine hydrochloride

There total 3 articles about Thiophen-3-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-aminothiophene (17721-06-1) → 3-aminothiophene hydrochloride (25475-76-7)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 0.05h;

Reference yield:

3-aminothiophene-2-carboxylic acid hydrochloride (1016552-72-9) → 3-aminothiophene hydrochloride (25475-76-7)

Guidance literature:

With hydrogenchloride; In dichloromethane; for 2h; Heating / reflux;

Reference yield:

tert-butyl 3-thienylcarbamate (19228-91-2) → 3-aminothiophene hydrochloride (25475-76-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 3h; Darkness; Reflux;

DOI:10.1002/cmdc.201800690

upstream raw materials:

3-aminothiophene

3-aminothiophene-2-carboxylic acid hydrochloride

tert-butyl 3-thienylcarbamate

Downstream raw materials:

2-phenyl-thieno[3,2-d]thiazole

thieno[3,2-b]pyridine-6-carbonitrile

Refernces

• 1、 -. "2-ALKENYL-3-AMINOTHIOPHENE DERIVATIVE AND METHOD FOR PRODUCING THE SAME". Page/Page column 12. . Retrieved 2009/01/24.
• 2、 Rault, S.,Cugnon de Sevricourt, M.,Robba, M.. "Nouvelle synthese et etude de la stabilite de l'amino-3 thiophene". . p. 205 - 208. Retrieved 2007/10/02.