1-Piperazinecarboxylic acid, 4-[(2S)-3-(3-cyanophenyl)-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulf onyl]amino]propyl]-, ethyl ester

Base Information

• Chemical Name: 1-Piperazinecarboxylic acid, 4-[(2S)-3-(3-cyanophenyl)-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulf onyl]amino]propyl]-, ethyl ester
• CAS No.: 255374-81-3
• Molecular Formula: C32H44N4O5S
• Molecular Weight: 596.791
• Mol file: 255374-81-3.mol

Synonyms:

Chemical Property of 1-Piperazinecarboxylic acid, 4-[(2S)-3-(3-cyanophenyl)-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulf onyl]amino]propyl]-, ethyl ester

Chemical Property:

• Boiling Point: 727.5±70.0 °C(Predicted)
• Density: 1.22±0.1 g/cm3(Predicted)

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Piperazinecarboxylic acid, 4-[(2S)-3-(3-cyanophenyl)-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulf onyl]amino]propyl]-, ethyl ester

There total 5 articles about 1-Piperazinecarboxylic acid, 4-[(2S)-3-(3-cyanophenyl)-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulf onyl]amino]propyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-ethoxycarbonylpiperazine (120-43-4) + Nα-2,4,6-Triisopropylphenylsulfonyl-(L)-3-cyano-phenylalanine (255374-80-2) → N-TIPPS-3-cyano-(L)-phenylalanine 4-ethoxycarbonylpiperazide (255374-81-3)

Guidance literature:

4-ethoxycarbonylpiperazine; Nα-2,4,6-Triisopropylphenylsulfonyl-(L)-3-cyano-phenylalanine; With benzotriazol-1-ol; In DMF (N,N-dimethyl-formamide); at 10 ℃; for 2h;

With dicyclohexyl-carbodiimide; In DMF (N,N-dimethyl-formamide); at 10 - 20 ℃;

Reference yield:

2,4,6-triisopropylphenylsulfonyl chloride (6553-96-4) → N-TIPPS-3-cyano-(L)-phenylalanine 4-ethoxycarbonylpiperazide (255374-81-3)

Guidance literature:

Multi-step reaction with 2 steps

2: DCC; HOBt

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; 1: amidation / 2: amidation;

DOI:10.1016/S0960-894X(99)00541-7

Reference yield:

3-cyano-(D,L)-phenylalanine (57213-48-6) → N-TIPPS-3-cyano-(L)-phenylalanine 4-ethoxycarbonylpiperazide (255374-81-3)

Guidance literature:

Multi-step reaction with 2 steps

2: DCC; HOBt

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; 1: amidation / 2: amidation;

DOI:10.1016/S0960-894X(99)00541-7

upstream raw materials:

4-ethoxycarbonylpiperazine

Nα-2,4,6-Triisopropylphenylsulfonyl-(L)-3-cyano-phenylalanine

2,4,6-triisopropylphenylsulfonyl chloride

3-cyano-(D,L)-phenylalanine

Downstream raw materials:

4-[(S)-3-(3-Thiocarbamoyl-phenyl)-2-(2,4,6-triisopropyl-benzenesulfonylamino)-propionyl]-piperazine-1-carboxylic acid ethyl ester

WX-UK₁