1-Piperazinecarboxylic acid, 4-[(2S)-3-(3-cyanophenyl)-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulf onyl]amino]propyl]-, ethyl ester

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 4-[(2S)-3-(3-cyanophenyl)-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulf onyl]amino]propyl]-, ethyl ester
CAS No.:255374-81-3
Molecular Formula:C32H44N4O5S
Molecular Weight:596.791
Hs Code.:
Mol file:255374-81-3.mol

Synonyms:

Suppliers and Price of 1-Piperazinecarboxylic acid, 4-[(2S)-3-(3-cyanophenyl)-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulf onyl]amino]propyl]-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperazinecarboxylic acid, 4-[(2S)-3-(3-cyanophenyl)-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulf onyl]amino]propyl]-, ethyl ester

Chemical Property:

Boiling Point:727.5±70.0 °C(Predicted)
Density:1.22±0.1 g/cm3(Predicted)

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 1-Piperazinecarboxylic acid, 4-[(2S)-3-(3-cyanophenyl)-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulf onyl]amino]propyl]-, ethyl ester

There total 5 articles about 1-Piperazinecarboxylic acid, 4-[(2S)-3-(3-cyanophenyl)-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulf onyl]amino]propyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 120-43-4
4-ethoxycarbonylpiperazine

: 255374-80-2
Nα-2,4,6-Triisopropylphenylsulfonyl-(L)-3-cyano-phenylalanine

: 255374-81-3
N-TIPPS-3-cyano-(L)-phenylalanine 4-ethoxycarbonylpiperazide

Guidance literature:: 4-ethoxycarbonylpiperazine; Nα-2,4,6-Triisopropylphenylsulfonyl-(L)-3-cyano-phenylalanine; With benzotriazol-1-ol; In DMF (N,N-dimethyl-formamide); at 10 ℃; for 2h;

With dicyclohexyl-carbodiimide; In DMF (N,N-dimethyl-formamide); at 10 - 20 ℃;

Reference yield:

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 255374-81-3
N-TIPPS-3-cyano-(L)-phenylalanine 4-ethoxycarbonylpiperazide

Guidance literature:: Multi-step reaction with 2 steps

2: DCC; HOBt

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; 1: amidation / 2: amidation;
DOI:10.1016/S0960-894X(99)00541-7

Reference yield:

: 57213-48-6
3-cyano-(D,L)-phenylalanine

: 255374-81-3
N-TIPPS-3-cyano-(L)-phenylalanine 4-ethoxycarbonylpiperazide

Guidance literature:: Multi-step reaction with 2 steps

2: DCC; HOBt

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; 1: amidation / 2: amidation;
DOI:10.1016/S0960-894X(99)00541-7