N-Benzyloxycarbonyl-D-proline

Base Information Edit

Chemical Name:N-Benzyloxycarbonyl-D-proline
CAS No.:6404-31-5
Molecular Formula:C13H15NO4
Molecular Weight:249.266
Hs Code.:29339900
European Community (EC) Number:229-021-5
DSSTox Substance ID:DTXSID60214085
Nikkaji Number:J207.010C
Wikidata:Q69756929
Mol file:6404-31-5.mol

Synonyms:6404-31-5;Z-D-Pro-OH;N-Benzyloxycarbonyl-D-proline;(+)-Z-D-proline;Z-D-PROLINE;(R)-N-BENZYLOXYCARBONYLPROLINE;N-Carbobenzoxy-D-proline;N-Cbz-D-proline;(2R)-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid;MFCD00063228;benzyloxycarbonyl-D-proline;(2R)-1-[(benzyloxy)carbonyl]pyrrolidine-2-carboxylic acid;((Benzyloxy)carbonyl)-D-proline;(R)-1-((Benzyloxy)carbonyl)pyrrolidine-2-carboxylic acid;EINECS 229-021-5;1-Benzyl hydrogen (R)-pyrrolidine-1,2-dicarboxylate;(R)-1-(BENZYLOXYCARBONYL)PYRROLIDINE-2-CARBOXYLIC ACID;1-[(benzyloxy)carbonyl]-d-proline;CBZ-D-PROLINE;N-benzyloxycarbonyI-D-proline;SCHEMBL475715;(+)-Z-D-proline, 98%;(2R)-N-benzyloxycarbonylproline;1-(benzyloxycarbonyl)-d-proline;N-(Benzyloxycarbonyl)-D-proline;DTXSID60214085;CS-M0865;(+)-CARBOBENZYLOXY-D-PROLINE;AKOS015924248;CCG-247547;(+)-N-CARBOBENZYLOXY-D-PROLINE;AC-24082;AS-12748;SY020327;AM20050504;C1730;EN300-121303;M03041;(2R)-1-benzyloxycarbonylpyrrolidine-2-carboxylate;A834624;J-300225;Q-101839;(R)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Suppliers and Price of N-Benzyloxycarbonyl-D-proline

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N-Benzyloxycarbonyl-D-proline
25g
$ 388.00

TRC
N-(Benzyloxycarbonyl)-D-proline
10g
$ 165.00

TCI Chemical
N-Carbobenzoxy-D-proline >98.0%(HPLC)(T)
25g
$ 159.00

TCI Chemical
N-Carbobenzoxy-D-proline >98.0%(HPLC)(T)
5g
$ 54.00

Sigma-Aldrich
(+)-Z-D-proline 98%
500mg
$ 52.90

Matrix Scientific
Z-D-Pro-OH 95+%
100g
$ 360.00

Matrix Scientific
Z-D-Pro-OH 95+%
10g
$ 70.00

Iris Biotech GmbH
Z-D-Pro-OH
5 g
$ 87.75

Iris Biotech GmbH
Z-D-Pro-OH
25 g
$ 236.25

Crysdot
Z-D-Pro-OH 97%
1000g
$ 317.00

Total 159 raw suppliers

Chemical Property of N-Benzyloxycarbonyl-D-proline Edit

Chemical Property:

Appearance/Colour:white to off-white crystalline powder
Vapor Pressure:3.06E-08mmHg at 25°C
Melting Point:76-78 °C(lit.)
Refractive Index:40 ° (C=2, EtOH)
Boiling Point:432.3 °C at 760 mmHg
PKA:3.99±0.20(Predicted)
Flash Point:215.3 °C
PSA：66.84000
Density:1.309 g/cm³
LogP:1.81010
Storage Temp.:Store at RT.
Solubility.:Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:249.10010796
Heavy Atom Count:18
Complexity:312

Purity/Quality:

98%min ^*data from raw suppliers

N-Benzyloxycarbonyl-D-proline ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1CC(N(C1)C(=O)OCC2=CC=CC=C2)C(=O)O
Isomeric SMILES:C1C[C@@H](N(C1)C(=O)OCC2=CC=CC=C2)C(=O)O
Uses N-(Benzyloxycarbonyl)-D-proline is an an N-Cbz-protected form of D-proline (P755990). It is used to prepare trichostatin A and trapoxin B analogs as histone deacetylase inhibitors. It is also used to prepare potent and selective nonpeptide inhibitors of caspases 3 and 7.

Technology Process of N-Benzyloxycarbonyl-D-proline

There total 21 articles about N-Benzyloxycarbonyl-D-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%