6-Benzoxazoleacetic acid, 2-[(2-methylphenyl)amino]-

Base Information

• Chemical Name: 6-Benzoxazoleacetic acid, 2-[(2-methylphenyl)amino]-
• CAS No.: 256453-94-8
• Molecular Formula: C16H14N2O3
• Molecular Weight: 282.299
• Mol file: 256453-94-8.mol

Synonyms:

Chemical Property of 6-Benzoxazoleacetic acid, 2-[(2-methylphenyl)amino]-

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Benzoxazoleacetic acid, 2-[(2-methylphenyl)amino]-

There total 2 articles about 6-Benzoxazoleacetic acid, 2-[(2-methylphenyl)amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

methyl 2-(2-methylphenylamino)-6-benzoxazolylacetate → 2-(2-methylphenylamino)-6-benzoxazolylacetic acid (256453-94-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; hydrogenchloride;

Reference yield:

(4-amino-3-hydroxy-phenyl)-acetic acid ethyl ester + 2-tolyl isothiocyanate (614-69-7) → 2-(2-methylphenylamino)-6-benzoxazolylacetic acid (256453-94-8)

Guidance literature:

(4-amino-3-hydroxy-phenyl)-acetic acid ethyl ester; 2-tolyl isothiocyanate; In ethanol; at 20 ℃;

With dicyclohexyl-carbodiimide; In ethanol; for 2h; Heating / reflux;

With sodium hydroxide; water; In ethanol; for 2h; Heating / reflux;

Reference yield: 100.0%

methyl 5-[(4S)-4-fluoro-(2S)-2-pyrrolidinylmethoxy]pentanoate + 2-(2-methylphenylamino)-6-benzoxazolylacetic acid (256453-94-8) + EDCúHCl → methyl 5-((2S,4S)-4-fluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-2-pyrrolidinylmethoxy)pentanoate (441714-08-5)

Guidance literature:

With benzotriazol-1-ol; triethylamine; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; chloroform; N,N-dimethyl-formamide; acetone;

upstream raw materials:

2-tolyl isothiocyanate

Downstream raw materials:

[1-{4-[2-[2-o-tolylamino-benzoxazol-6-yl]-acetylamino]-phenyl}-cyclopentyl]-acetic acid tert-butyl ester

(2-(4-(2-(2-o-tolylamino-benzoxazol-6-yl)-acetylamino)-phenyl)-indan-2-yl)-acetic acid ethyl ester

(5-[2-{2-o-Tolylamino-benzoxazol-6-yl}-acetylamino]-indan-2-yl)-acetic acid

ethyl 3-{7-[2-(2-o-tolylamino-benzoxazol-6-yl)-acetylamino]-indan-4-yl}-butanoate