methyl 5-((2S,4S)-4-fluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-2-pyrrolidinylmethoxy)pentanoate

Base Information

Chemical Name:methyl 5-((2S,4S)-4-fluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-2-pyrrolidinylmethoxy)pentanoate
CAS No.:441714-08-5
Molecular Formula:C₂₇H₃₂FN₃O₅
Molecular Weight:497.567
Hs Code.:

Synonyms:methyl 5-((2S,4S)-4-fluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-2-pyrrolidinylmethoxy)pentanoate

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Chemical Property of methyl 5-((2S,4S)-4-fluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-2-pyrrolidinylmethoxy)pentanoate

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Technology Process of methyl 5-((2S,4S)-4-fluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-2-pyrrolidinylmethoxy)pentanoate

There total 2 articles about methyl 5-((2S,4S)-4-fluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-2-pyrrolidinylmethoxy)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: methyl 5-[(4S)-4-fluoro-(2S)-2-pyrrolidinylmethoxy]pentanoate

: 256453-94-8
2-(2-methylphenylamino)-6-benzoxazolylacetic acid

: EDCúHCl

: 441714-08-5
methyl 5-((2S,4S)-4-fluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-2-pyrrolidinylmethoxy)pentanoate

Guidance literature:: With benzotriazol-1-ol; triethylamine; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; chloroform; N,N-dimethyl-formamide; acetone;

Reference yield:

: methyl 5-[(4S)-4-fluoro-(2S)-2-pyrrolidinylmethoxy]pentanoate

: 256453-94-8
2-(2-methylphenylamino)-6-benzoxazolylacetic acid

: 441714-08-5
methyl 5-((2S,4S)-4-fluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-2-pyrrolidinylmethoxy)pentanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.bmc.2008.12.026

Reference yield:

: 441714-08-5
methyl 5-((2S,4S)-4-fluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-2-pyrrolidinylmethoxy)pentanoate

: 441712-07-8
5-[(4S)-fluoro-1-[2-(2-methylphenyl)amino-6-benzoxazolylacetyl]-(2S)-pyrrolidinylmethoxy]pentanoic acid

Guidance literature:: methyl 5-((2S,4S)-4-fluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-2-pyrrolidinylmethoxy)pentanoate; With sodium hydroxide; water; In tetrahydrofuran; at 50 ℃; for 17h;

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmc.2008.12.026