Methanone, (2-methoxyphenyl)[4-(trifluoromethyl)phenyl]-

Base Information

• Chemical Name: Methanone, (2-methoxyphenyl)[4-(trifluoromethyl)phenyl]-
• CAS No.: 256475-07-7
• Molecular Formula: C15H11F3O2
• Molecular Weight: 280.246
• Mol file: 256475-07-7.mol

Synonyms:Methanone, (2-methoxyphenyl)[4-(trifluoromethyl)phenyl]-;2-methoxyphenyl 4-trifluoromethylphenyl methanone;

Chemical Property of Methanone, (2-methoxyphenyl)[4-(trifluoromethyl)phenyl]-

Chemical Property:

• PSA: 26.30000
• LogP: 3.94500

Purity/Quality:

95% ^*data from raw suppliers

2-Methoxy-4'-trifluoromethylbenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanone, (2-methoxyphenyl)[4-(trifluoromethyl)phenyl]-

There total 11 articles about Methanone, (2-methoxyphenyl)[4-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Methoxyphenylboronic acid (5720-06-9) + p-trifluoromethylbenzoic acid phenyl ester (106376-16-3) → (2-methoxyphenyl)[4-(trifluoromethyl)phenyl]methanone (256475-07-7)

Guidance literature:

With (3-phenylallyl)(chloro)-[1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene]palladium(II); water; potassium hydroxide; In 2-methyltetrahydrofuran; at 23 ℃; for 15h; chemoselective reaction; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1002/adsc.201901188

Reference yield: 97.0%

4-iodoanisol (529-28-2) + 4-trifluoromethylphenylboronic acid (128796-39-4) + chromium(0) hexacarbonyl (199620-14-9,13007-92-6) → (2-methoxyphenyl)[4-(trifluoromethyl)phenyl]methanone (256475-07-7)

Guidance literature:

With sodium t-butanolate; In N,N-dimethyl acetamide; at 80 ℃; for 0.75h;

DOI:10.1007/s10562-019-03087-w

Reference yield: 97.0%

1-(4-(trifluoromethyl)benzoyl)piperidine-2,6-dione + (2-methoxyphenyl)zinc chloride → (2-methoxyphenyl)[4-(trifluoromethyl)phenyl]methanone (256475-07-7)

Guidance literature:

1-(4-(trifluoromethyl)benzoyl)piperidine-2,6-dione; With bis(triphenylphosphine)nickel(II) chloride; In diethyl ether; at 23 ℃; for 0.0833333h; Inert atmosphere; Schlenk technique;

(2-methoxyphenyl)zinc chloride; In tetrahydrofuran; diethyl ether; at 23 ℃; for 12h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201602202

upstream raw materials:

2-methoxy-N-methoxy-N-methylbenzamide

(4-trifluoromethylphenyl)lithium

4-trifluoromethylbenzoic acid

methoxybenzene

Downstream raw materials:

(2-hydroxyphenyl)[4-(trifluoromethyl)phenyl]methanone

C₁₈H₁₇F₃O₂

C₁₈H₁₅F₃O₂

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