1H-Indole, 5-(4,5-dihydro-5-(3,4,5-trimethoxyphenyl)-2-oxazolyl)-1-methyl-

Base Information

Chemical Name:1H-Indole, 5-(4,5-dihydro-5-(3,4,5-trimethoxyphenyl)-2-oxazolyl)-1-methyl-
CAS No.:256934-83-5
Molecular Formula:C21H22N2O4
Molecular Weight:
Hs Code.:
UNII:R8R0A9C5SI
Nikkaji Number:J1.668.616F
Wikidata:Q27287976
ChEMBL ID:CHEMBL343962
Mol file:256934-83-5.mol

Synonyms:A 289099;A-289099;A289099

Suppliers and Price of 1H-Indole, 5-(4,5-dihydro-5-(3,4,5-trimethoxyphenyl)-2-oxazolyl)-1-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Indole, 5-(4,5-dihydro-5-(3,4,5-trimethoxyphenyl)-2-oxazolyl)-1-methyl-

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:366.15795719
Heavy Atom Count:27
Complexity:528

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C=CC2=C1C=CC(=C2)C3=NCC(O3)C4=CC(=C(C(=C4)OC)OC)OC

Technology Process of 1H-Indole, 5-(4,5-dihydro-5-(3,4,5-trimethoxyphenyl)-2-oxazolyl)-1-methyl-

There total 13 articles about 1H-Indole, 5-(4,5-dihydro-5-(3,4,5-trimethoxyphenyl)-2-oxazolyl)-1-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 91634-11-6
N-methyl-5-cyanoindole

: 256935-68-9
(1S)-2-amino-1-(3,4,5-trimethoxyphenyl)ethanol

: 256934-83-5
1-methyl-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-1H-indole

Guidance literature:: With potassium carbonate; In ethylene glycol; glycerol; at 140 ℃; for 40h;
DOI:10.1016/S0960-894X(01)00759-4

Reference yield: 52.0%

: 1-methyl-1H-indole-5-carboxylic acid N-[2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]amide

: 256934-83-5
1-methyl-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-1H-indole

Guidance literature:: With methoxycarbonylsulfamoyl-triethylammmonium hydroxide; In tetrahydrofuran; for 1h; Heating;
DOI:10.1021/jm010231w

Reference yield:

: 13400-02-7
3,4,5-trimethoxy styrene

: 256934-83-5
1-methyl-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1: AD-mix-β / 2-methyl-propan-2-ol; H2O / 0 - 20 °C

2: pyridine / 2 h / 0 °C

3: NaN₃ / dimethylformamide / 2 h / 85 °C

4: H₂ / 10 percent Pd/C / 20 °C

5: K₂CO₃ / ethane-1,2-diol; glycerol / 40 h / 140 °C

With pyridine; sodium azide; AD-mix-β; hydrogen; potassium carbonate; palladium on activated charcoal; In water; ethylene glycol; N,N-dimethyl-formamide; glycerol; tert-butyl alcohol;
DOI:10.1016/S0960-894X(01)00759-4