4-(1H-imidazol-1-yl)pyridine

Base Information

• Chemical Name: 4-(1H-imidazol-1-yl)pyridine
• CAS No.: 25700-16-7
• Molecular Formula: C8H7N3
• Molecular Weight: 145.16100
• European Community (EC) Number: 844-743-6
• DSSTox Substance ID: DTXSID701309602
• Nikkaji Number: J2.314.273B
• Mol file: 25700-16-7.mol

Synonyms:4-(1H-imidazol-1-yl)pyridine;4-imidazol-1-ylpyridine;25700-16-7;1-(4-pyridyl)-1H-imidazole;SCHEMBL3250899;YSCK0366;BDBM84679;1-Subsituted 1H-imidazole, 16;JNDMBEDJCZRWLO-UHFFFAOYSA-N;DTXSID701309602;AKOS000268321;CS-0248634;EN300-40763;Z234895131

Chemical Property of 4-(1H-imidazol-1-yl)pyridine

Chemical Property:

• PSA: 30.71000
• LogP: 1.26730
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 145.063997236
• Heavy Atom Count: 11
• Complexity: 121

Purity/Quality:

99% ^*data from raw suppliers

4-(1H-imidazol-1-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CN=CC=C1N2C=CN=C2

Technology Process of 4-(1H-imidazol-1-yl)pyridine

There total 9 articles about 4-(1H-imidazol-1-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1H-imidazole (288-32-4) + 4-Chloropyridine (626-61-9) → 1-(pyridin-4-yl)-1H-imidazole (25700-16-7)

Guidance literature:

With potassium carbonate; copper(II) oxide; In N,N-dimethyl-formamide; at 120 ℃; for 18h;

DOI:10.1002/adsc.200600483

Reference yield: 92.0%

1H-imidazole (288-32-4) + 4-bromopyridin (1120-87-2) → 1-(pyridin-4-yl)-1H-imidazole (25700-16-7)

Guidance literature:

With Cu(II)-exchanged fluorapatite; potassium carbonate; In dimethyl sulfoxide; at 110 ℃; for 6h;

DOI:10.1016/j.tetlet.2006.03.173

Reference yield: 77.0%

4-methoxypyridine N-oxide (1122-96-9) + N-tosylimidazole (2232-08-8) → 2-(1H-imidazol-1-yl)-4-methoxypyridine + 1-(pyridin-4-yl)-1H-imidazole (25700-16-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 100 ℃; for 3h; Inert atmosphere; Neat (no solvent);

DOI:10.1021/jo1001017

upstream raw materials:

1H-imidazole

4-Chloropyridine

4-bromopyridin

4-chloropyridine N-oxide

Downstream raw materials:

4-(1H-imidazol-1-yl)-piperidine