4-Methoxypyridine N-oxide

Base Information

• Chemical Name: 4-Methoxypyridine N-oxide
• CAS No.: 1122-96-9
• Molecular Formula: C6H7NO2
• Molecular Weight: 125.127
• Hs Code.: 29333990
• European Community (EC) Number: 214-367-1
• NSC Number: 27964
• UNII: UMB9SBP2LF
• DSSTox Substance ID: DTXSID30149956
• Nikkaji Number: J182.502J
• Wikidata: Q63392151
• Mol file: 1122-96-9.mol

Synonyms:4-Methoxypyridine N-oxide;1122-96-9;4-Methoxypyridine 1-oxide;4-Methoxypyridine-N-oxide;4-methoxy-1-oxidopyridin-1-ium;Pyridine, 4-methoxy-, 1-oxide;MFCD00006207;NSC-27964;4-METHOXYPYRIDIN-1-IUM-1-OLATE;4-MethoxypyridineN-oxide;NSC27964;UMB9SBP2LF;4-methoxypiridine-N-oxide;4-Methoxylpyridine N-Oxide;4-methoxypyridine--N-oxide;4-Methoxy pyridine N-oxide;4-methoxy-pyridine-1-oxide;4-Methoxy-pyridine 1-oxide;SCHEMBL503712;Pyridine, 4-methoxy-1-oxide-;DTXSID30149956;EINECS 214-367-1;AKOS000281799;AB00619;AC-4673;AMY202100010;CS-10614;SY070179;CS-0376314;FT-0618963;M2401;A802545;Q-101514;4-Methoxypyridine N-oxide hydrate, technical, >=90%;Q63392151

Chemical Property of 4-Methoxypyridine N-oxide

Chemical Property:

• Appearance/Colour: crystalline powder
• Vapor Pressure: 1.55E-07mmHg at 25°C
• Melting Point: 104-106 °C
• Boiling Point: 308.9 °C at 760 mmHg
• PKA: 2.30±0.10(Predicted)
• Flash Point: 140.6 °C
• PSA: 34.69000
• Density: 1.09 g/cm³
• LogP: 1.12370
• Storage Temp.: Refrigerator
• Sensitive.: Hygroscopic
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 125.047678466
• Heavy Atom Count: 9
• Complexity: 79.1

Purity/Quality:

99.9% ^*data from raw suppliers

4-Methoxypyridine N-Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-24/25-37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=[N+](C=C1)[O-]
• Uses: 4-Methoxypyridine N-oxide is a heteroaromatic N-oxide used as a nucleophilic catalyst in oligonucleotide synthesis and free radical polymerization.

Technology Process of 4-Methoxypyridine N-oxide

There total 47 articles about 4-Methoxypyridine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methanol (67-56-1) + 4-nitraminopyridine N-oxide (1124-33-0) → 4-methoxypyridine N-oxide (1122-96-9)

Guidance literature:

With sodium; Heating;

DOI:10.1002/ejoc.200400232

Reference yield: 89.0%

4-methoxypyridine (620-08-6,1232006-56-2) → 4-methoxypyridine N-oxide (1122-96-9)

Guidance literature:

With dihydrogen peroxide; acetic acid; for 24h; Reflux;

DOI:10.1021/jo4012514

Reference yield: 87.0%

methanol (67-56-1) + 4-(N-pyridinium)pyridine-N-oxide chloride tetracyanoethylene complex (137858-02-7) → 4-methoxypyridine N-oxide (1122-96-9)

Guidance literature:

With sodium methylate; for 24h; Ambient temperature;

DOI:10.1007/BF01169672

upstream raw materials:

diazomethane

1-hydroxy-1H-pyridin-4-one

4-bromopyridine-1-oxide

sodium methylate

Downstream raw materials:

2-(4'-methoxy-2'-pyridyl)cyclohexanone

3-cyano-2-phenylfuro<3,2-c>pyridine

4-Methoxy-1-[N-((6R,7R)-2-methoxycarbonyl-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-yl)-2-phenoxy-acetimidoyloxy]-pyridinium

(6R,7R)-3-Methyl-8-oxo-7-[1-(4-oxo-4H-pyridin-1-yloxy)-2-phenoxy-eth-(Z)-ylideneamino]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester