2H-Pyran, tetrahydro-2-[(3-phenyl-2-propynyl)oxy]-

Base Information

• Chemical Name: 2H-Pyran, tetrahydro-2-[(3-phenyl-2-propynyl)oxy]-
• CAS No.: 25724-96-3
• Molecular Formula: C14H16O2
• Molecular Weight: 216.28
• DSSTox Substance ID: DTXSID80470262
• Nikkaji Number: J546.170G
• Mol file: 25724-96-3.mol

Synonyms:2H-Pyran, tetrahydro-2-[(3-phenyl-2-propynyl)oxy]-;25724-96-3;DTXSID80470262;2-(3-Phenyl-prop-2-ynyloxy)-tetrahydro-pyran

Chemical Property of 2H-Pyran, tetrahydro-2-[(3-phenyl-2-propynyl)oxy]-

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 216.115029749
• Heavy Atom Count: 16
• Complexity: 254

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCOC(C1)OCC#CC2=CC=CC=C2

Technology Process of 2H-Pyran, tetrahydro-2-[(3-phenyl-2-propynyl)oxy]-

There total 6 articles about 2H-Pyran, tetrahydro-2-[(3-phenyl-2-propynyl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

iodobenzene (591-50-4) + 3-(tetrahydropyran-2'-yloxy)propyne (6089-04-9) → 2-<(3-Phenyl-2-propynyl)oxy>-3,4,5,6-tetrahydro-2H-pyran (25724-96-3)

Guidance literature:

copper(l) iodide; potassium carbonate; triphenylphosphine; In dimethyl sulfoxide; at 120 ℃; for 24h;

DOI:10.1021/jo00069a040

Reference yield: 68.0%

3-Phenyl-2-propyn-1-ol (1504-58-1) + 4,4,5,5-tetramethyl-2-(tetrahydro-2H-pyran-2-yl)-1,3,2-dioxaborolane → 2-<(3-Phenyl-2-propynyl)oxy>-3,4,5,6-tetrahydro-2H-pyran (25724-96-3)

Guidance literature:

With [bis(acetoxy)iodo]benzene; manganese(II) acetate; copper(II) bis(trifluoromethanesulfonate); In chloroform; at 60 ℃; for 5h; Molecular sieve;

DOI:10.1021/acs.joc.0c00720

Reference yield: 62.0%

iodobenzene (591-50-4) + C17H32BO5(1-)*Li(1+) → 2-<(3-Phenyl-2-propynyl)oxy>-3,4,5,6-tetrahydro-2H-pyran (25724-96-3)

Guidance literature:

copper(l) iodide; tetrakis(triphenylphosphine)platinum; In N,N-dimethyl-formamide; at 120 ℃; for 10h;

DOI:10.1055/s-2004-832819

upstream raw materials:

iodobenzene

3-(tetrahydropyran-2'-yloxy)propyne

chlorobenzene

3-Phenyl-2-propyn-1-ol

Downstream raw materials:

3-phenyl-2-propyn-1-yl methanesulfonate

1-phenylpropa-1,2-dien-1-yl diphenyl phosphine oxide

3-phenyl-2(5H)-furanone

3-Phenyl-hexa-1,2-dien-4-ol