3-Methyl-2-(tributylstannyl)pyridine

Base Information

• Chemical Name: 3-Methyl-2-(tributylstannyl)pyridine
• CAS No.: 259807-97-1
• Molecular Formula: C18H33NSn
• Molecular Weight: 382.177
• Hs Code.: 2933399090
• European Community (EC) Number: 677-932-5
• DSSTox Substance ID: DTXSID20586018
• Wikidata: Q72491864
• Mol file: 259807-97-1.mol

Synonyms:3-Methyl-2-(tributylstannyl)pyridine;259807-97-1;Pyridine, 3-methyl-2-(tributylstannyl)-;tributyl-(3-methylpyridin-2-yl)stannane;2-(tributylstannyl)-3-methylpyridine;MFCD07787404;SCHEMBL1278237;DTXSID20586018;QWDWZQDTTVYOBK-UHFFFAOYSA-N;3-methyl-2-tributylstannanylpyridine;AKOS015841924;GS-6528;2-(tri-n-butylstannyl)-3-methylpyridine;3-Methyl-2-(tri-n-butylstannyl)pyridine;AM803601;DA-23386;SY021071;CS-0040960;EN300-730083;F11335;3-methyl-2-(tributylstannyl)pyridine, AldrichCPR;A877408;J-506641

Chemical Property of 3-Methyl-2-(tributylstannyl)pyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 396.76oC at 760 mmHg
• Flash Point: 193.754oC
• PSA: 12.89000
• LogP: 5.44610
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Sparingly soluble in water.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 10
• Exact Mass: 383.163503
• Heavy Atom Count: 20
• Complexity: 220

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methyl-2-(tributylstannyl)pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC[Sn](CCCC)(CCCC)C1=C(C=CC=N1)C
• Uses: 3-Methyl-2-(tri-n-butylstannyl)pyridine is used as pharmaceutical intermediate.

Technology Process of 3-Methyl-2-(tributylstannyl)pyridine

There total 4 articles about 3-Methyl-2-(tributylstannyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

tributyltin chloride (1461-22-9) → 3-methyl-2-(tributylstannanyl)pyridine (259807-97-1)

Guidance literature:

2-bromo-3-picoline; With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 0.25h;

tributyltin chloride; In tetrahydrofuran; hexane; for 1h;

Reference yield: 27.0%

2-bromo-3-picoline (3430-17-9) + tributyltin chloride (1461-22-9) → 3-methyl-2-(tributylstannanyl)pyridine (259807-97-1)

Guidance literature:

2-bromo-3-picoline; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

tributyltin chloride; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

Reference yield: 24.0%

2-fluoro-3-methylpyridine (2369-18-8) + trimethylsilyltributyltin (17955-46-3) → 3-methyl-2-(tributylstannanyl)pyridine (259807-97-1)

Guidance literature:

With cesium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Irradiation; Schlenk technique; Sealed tube;

DOI:10.1021/jacs.1c00887

upstream raw materials:

tributyltin chloride

2-bromo-3-picoline

2-fluoro-3-methylpyridine

trimethylsilyltributyltin

Refernces

• 1、 -. "SUBSTITUTED 7-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS". Paragraph 0332. . Retrieved 2016/03/13.
• 2、 -. "NOVEL SULFONYL DERIVATIVES". . . Retrieved 2008/06/13.