2369-18-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-3-methylpyridine is used as an intermediate compound for the preparation of various pharmaceutically relevant molecules, such as:
2-phenyl-3-methylpyridine
2-(4-chlorophenyl)-3-methylpyridine
2-(4-fluorophenyl)-3-methylpyridine
2-fluoronicotinic acid
These synthesized compounds can be further utilized in the development of new drugs and therapeutic agents, potentially targeting a range of medical conditions and diseases.

InChI:InChI=1/C6H3Br2F/c7-5-2-1-4(9)3-6(5)8/h1-3H

Upstream product

• 1603-40-3 3-methylpyridin-2-ylamine 
• 108-99-6 3-Methylpyridine 
• 75-05-8 acetonitrile 
• 113975-22-7 2-fluoro-3-iodopyridine 
• 31729-70-1 bis(iodozinc)methane 

Downstream Products

• 393-55-5 2-fluoronicotinic acid 
• 315180-14-4 3-(chloromethyl)-2-fluoropyridine 
• 847687-58-5 (2S)-2-[(S)-[(3-methylpyridin-2-yl)thio](phenyl)methyl]-4-(phenylmethyl)morpholine 
• 867012-70-2 6-methoxy-5-methylpyridin-3-amine 
• 89694-10-0 2-methoxy-3-methyl-5-nitropyridine 
• 1003-56-1 3-Methyl-1H-pyridin-2-one 
• 101419-76-5 2-(4-fluorophenyl)-3-methylpyridine 
• 10273-90-2 2-phenyl-3-methylpyridine 
• 101419-77-6 2-(4-chlorophenyl)-3-methylpyridine 
• 259807-97-1 3-methyl-2-(tributylstannanyl)pyridine 
• 4930-99-8 3-methyl-pyridin-2-ylhydrazine 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 104396-10-3 1-(3-Methyl-2-pyridinyl)piperazine 
• 1263086-49-2 C₁₉H₂₀N₂O₃ 

Relevant academic research and scientific papers

Preparation of an Arenylmethylzinc Reagent with Functional Groups by Chemoselective Cross-Coupling Reaction of Bis(iodoazincio)methane with Iodoarenes

Palladium-catalyzed cross-coupling reaction of bis(iodozincio)methane with iodoarenes carrying various functionalities such as ester, boryl, cyano, and halo groups proceeded chemoselectively to give the corresponding arenylmethylzinc species efficiently. The moderate reactivity of the gem-dizinc reagent imparted functional group tolerance to the process. The transformations from iodoheteroarenes were also performed; in the case of iodopyridine derivatives, the nickel-catalyzed reaction gave the corresponding organozinc species efficiently. The obtained arenylmethylzinc species underwent the copper-mediated coupling reaction with a range of organic halides.

Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning

Fluoroheterocyclic aldoximes were screened as therapeutic agents for the treatment of anticholinesterase poisoning. 2-Fluoropyridine-3- and -6-aldoxime, and 3-fluoropyridine-2- and -4-aldoxime, were synthesised. Attempts to obtain 3,5,6-trifluoropyridine-2,4-bis(aldoxime) and -2-aldoxime, however, proved unsuccessful. Pentafluorobenzaldoxime was prepared by oximation of pentafluorobenzaldehyde. Acid dissociation constants (pKa) and second-order rate constants (kox-) of the fluorinated pyridinealdoximes towards sarin were measured. 2,3,5,6-Tetrafluoropyridine-4- aldoxime had the best profile: its kox- approached that of the therapeutic oxime P2S (310 vs. 120 l mol-1 min-1), but its higher pKa (9.1 vs. 7.8) fell short of the target figure of 8 required for reactivation of inhibited acetylcholinesterase in vivo. N-alkylation of the fluorinated pyridine-aldoximes may reduce their pK a nearer to 8 and enhance their therapeutic potential. Crown Copyright

Carboxamidation of pyridines by the system of elemental fluorine- carbonitrile-water: A useful alternative to the chichibabin amination

The title reaction with pyridine, 4-methylpyridine, 3-methylpyridine, 3- bromopyridine, nicotinonitrile, and quinoline yields 2-carboxamido derivatives regioselectively. Isoquinoline is amidated at position 1.

DIRECT FLUORINATION OF SUBSTITUTED PYRIDINES

The direct fluorination of pyridines bearing alkyl, halogen, ester, or ketone functions has been employed to prepare the corresponding 2-fluoro-substituted pyridines.